Titremede serebellum ve sensorimotor ağın dinamik telafisi Parkinson hastalığına hakim oldu

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Aim: Parkinson's disease(PD) tremor was the symptom that associated basal ganglia(BG), cerebellum(CB), and sensorimotor(SMN) networks, we investigated the tremor-related static functional network connectivity(SFNC) and dynamic functional network connectivity(DFNC). Methods: : We analyzed the resting-state functional MRI data of 21 tremor-dominant Parkinson's disease (TDPD) patients and 29 healthy controls (HC). Then we compared the DFNC and SFNC of the three networks and examined their associations with tremor symptoms. Results: : In TDPD patients, the SFNC between SMN and BG networks was increased. Patients with TDPD spent more mean dwell time (MDT) in state 2 indicating sparse connections and less MDT in state 4 indicating stronger connections. DFNC between the cerebellum and SMN in state 2 was enhanced. The MDT of state 2 was positively associated with tremor scores. Conclusion: The increased connection between the cerebellum and sensorimotor region was a result of dynamic compensation, TDPD patients were more likely to remain in the condition of sparse connection.

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