Parkinson hastalığı hastalarının yapısal ve fonksiyonel manyetik rezonans görüntüleme kullanarak gastrointestinal semptomlarının analizi

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Abstract Objective: Gastrointestinal symptoms are one of the most common non-motor symptoms in Parkinson’s disease. This study aimed to investigate the neuroimaging mechanisms underlying gastrointestinal symptoms associated with Parkinson’s disease using functional connectivity and voxel-based morphometry. Methods: The study included 50 healthy controls, 71 Parkinson’s disease patients without gastrointestinal symptoms and 84 patients with gastrointestinal symptoms. Differences in gray matter volume among the three groups were assessed. Given a significant decrease in gray matter volume in the right cerebellar hemisphere, it was selected as the seed region for functional connectivity analysis. Results: The Parkinson’s disease patients with gastrointestinal symptoms showed significant differences in disease duration, levodopa equivalents daily dose, Hoehn and Yahr stage, unified Parkinson's disease rating scale part Ⅲ, Hamilton anxiety scale, Scales for Outcomes in Parkinson’s disease-Autonomic, non-motor symptom scale, Montreal cognitive assessment, and orthostatic hypotension compared to the patients without gastrointestinal symptoms (pConclusions: Parkinson’s disease patients with gastrointestinal symptoms present with a prolonged disease course and increased severity of both motor and non-motor symptoms. The gastrointestinal symptoms in Parkinson’s disease patients may be associated with structural and functional brain alterations.

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