Alfa-sinüklein üzerinde Boswellic Acid ile Conjugated Altın Nanopartiküllerin Anti-fibrilasyon Etkisi

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Abstract Neurodegenerative diseases such as Alzheimer’s and Parkinson’s are characterized by the death of neurons in specific brains. α-synuclein (α-Syn) is a key factor in Parkinson’s disease (PD), forming toxic fibrils when misfolded. Natural products, such as Boswellia serrata, have shown promise in treating neurodegenerative diseases. However, the poor pharmacological performance of Boswellia acids (BAs) limits their effectiveness. Enhancing the bioavailability of BAs through nanocarriers could be a solution. This study explores the potential of β-Boswellic acid conjugated to gold nanoparticles (GNPs) as a novel PD treatment. Covalent and noncovalent conjugations of β-Boswellic acid to GNPs (GNP-BA) were developed to study their impact on α-Syn fibrillation in vitro. The successful synthesis of spherical GNPs (

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