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Abstract Background: Parkinson’s disease is a progressive disease that causes damage to parts of the brain. It is the most common motor brain condition. This study aims to investigate the prevalence, knowledge, and attitude toward Parkinson’s disease among the general population in Saudi Arabia. Objective: To investigate the prevalence, knowledge, and attitude toward Parkinson’s disease among the general population in Saudi Arabia. Methods: This cross-sectional study was conducted in Saudi Arabia from July 20 to November 20, 2024, targeting adults aged 18 and older. Participants (n = 385) were randomly selected via social media platforms, using a bilingual (Arabic and English) online questionnaire. The survey included demographics, self-reported PD prevalence, knowledge, and attitudes. Data was analyzed using SPSS (version 28), with ethical approval obtained. Results: A total of 330 participants were surveyed, mostly young (292, 88.5% aged 18–24), female (269, 81.5%), and students (281, 85.2%). Nearly half (162, 49.1%) had heard of PD, but only 81 (24.5%) showed good knowledge, with misconceptions about causes and treatment. Commonly recognized symptoms included hand tremors (292, 88.5%) and poor balance (210, 63.6%), while awareness of non-motor symptoms was low. Most participants (319, 96.7%) supported public education, and 310 (93.9%) recommended social support for PD patients. Conclusion: This study emphasizes gaps in public knowledge about Parkinson's disease in Saudi Arabia. The results highlight the need for educational efforts to improve understanding and address misconceptions. Categories: Neuroscience
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