Parkinson hastalığında subtalamik yerel alan potansiyellerinde aperiyodik ve periyodik fizyografların uzun süreli tutarlılığı

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Abstract Beta oscillations (± 13-35 Hz) and aperiodic spectral features extracted from local field potential (LFP) recordings have been identified as promising physiomarkers for adaptive deep brain stimulation (aDBS) in Parkinson's disease. However, the long-term consistency of these signal features in patients years after DBS implantation is still unclear. Bilateral subthalamic nucleus LFPs were recorded from twelve patients with an average inter-recording interval of 137 days, during rest, a finger-to-nose task and speech, with stimulation switched off and on. Intra-class correlation coefficients indicated moderate between-visit consistency for the aperiodic offset and exponent but good to excellent consistency of beta peak power. Task execution and stimulation induced aperiodic and power changes that were statistically comparable across visits. Results remained inconclusive regarding which beta peaks exhibited the strongest power suppression post-stimulation. Our findings support the potential of beta peak power as a primary physiomarker for aDBS, with aperiodic components serving as supplementary markers.

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