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TMEM106B risk converges on C-terminal fragment homeostasis: genetics, mechanisms and therapy.

Lastra Osua M, Perneel J, Vicente CT, Rademakers R.

Brain · 2026-10-22

DOI: 10.1093/brain/awag367PMID: 42910644

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Genetic and personality interactions shape impulse control disorders in Parkinson's disease.

Boussac M, Bastos PAD, Wirth T, Lanore A, Harroch E, Mariani LL, Anheim M, Corvol JC, Brefel-Courbon C, BADGE-PD study group.

J Parkinsons Dis · 2026-10-22

DOI: 10.1177/1877718x261499529PMID: 42911097

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Prevalence of alpha-synuclein seeding activity in the Olfactory Mucosa following SARS-CoV-2 infection: results from a pilot study.

Heim B, Seppi K, De Cleene N, Bongianni M, Bronzato E, Cerejo C, Jagusch F, Kindl P, Löffler-Ragg J, Weiss G, Gottfried T, Schmutzhard J, Zanusso G, Poewe W.

Acta Neuropathol · 2026-10-22

DOI: 10.1007/s00401-026-03104-4PMID: 42911254

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Phosphorylation of α-Synuclein Directs Trafficking of the v-SNARE Synaptobrevin-2.

Arvell EH, Carroll JP, Melland H, Engholm-Keller K, Hatters DM, Graham ME, Gordon SL.

J Neurosci · 2026-10-21

DOI: 10.1523/jneurosci.1860-25.2026PMID: 42711125

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The GBA1-related variant rs12411216 is Associated with Motor and Non-Motor Impairments and Unfavorable Progression in Parkinson's Disease: A Five-Year Longitudinal Study.

Bragina E, Nikitina M, Skorikov N, Shipulina S, Alifirova V, Nazarenko M.

J Mol Neurosci · 2026-10-21

DOI: 10.1007/s12031-026-02615-9PMID: 42905360

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Astrocyte-enriched and cilia-related genetic signatures in dementia: A whole-exome sequencing study.

Deng M, Chen Y, Zhao L, Song W, Qiu Q, Sun L, Lin X, Wang W, Lin GN, Li X.

Gen Psychiatr · 2026-10-21

DOI: 10.1002/gps3.70062PMID: 42910247

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Parkinson's disease-associated genetic alterations disrupt behavior and diurnal activity in Drosophila melanogaster.

Witte C, Mitra S, Lackey K, Krishnan N, Chaudhuri A.

Behav Brain Res · 2026-10-20

DOI: 10.1016/j.bbr.2026.116538PMID: 42901419

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Discovery of benzoxazole derivatives as novel α-synuclein aggregate ligands with potential for PET tracer development.

Wang Y, Qin J, Zhang Y, Wang Y, Ji B, Chu Y.

Eur J Med Chem · 2026-10-20

DOI: 10.1016/j.ejmech.2026.119448PMID: 42906388

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Enteric alpha-synuclein pathology in early-onset parkinsonism: Findings in a patient with SCA6.

Yun JY, Shin C, Kim SI, Kim JM, Lee JY, Chung SJ, Kim JW, Ahn TB, Park KW, Shin JH, Lee HJ, Kong SH, Suh YS, Kim HJ, Yang HK, Park SH, Jeon B.

Parkinsonism Relat Disord · 2026-10-20

DOI: 10.1016/j.parkreldis.2026.109025PMID: 42925589

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Cerebrospinal fluid and dural accumulation of α-synuclein impairs CNS clearance in Parkinson's disease.

Stevenson TJ, Vinnell L, McCullough SJC, Flyger DX, Highet B, Wiseman JA, Watkin B, Hitpass Romero K, Low VF, Smith AM, Wu A, Fong DM, Grimsey NL, Dieriks BV, Turner CP, Young D, Curtis MA, Faull RLM, Dragunow M, Rustenhoven J.

J Exp Med · 2026-10-20

DOI: 10.1084/jem.20251245PMID: 42900184

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Swollen lysosomes grab Rabs for a CASM-free route to LRRK2 activation.

Pfeffer SR.

J Cell Biol · 2026-10-20

DOI: 10.1083/jcb.202610007PMID: 42900583

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ClC-7 links PIKfyve inhibition to Rab-dependent LRRK2 activity at lysosomes.

Clegg D, Bentley-DeSousa A, Roczniak-Ferguson A, Ferguson SM.

J Cell Biol · 2026-10-20

DOI: 10.1083/jcb.202511137PMID: 42900584

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