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LRRK2 p.G2385R and p.R1628P variants in a multi-ethnic Asian Parkinson's Cohort: epidemiology and clinical insights.

Goh JW, Lim JL, Toh TS, Ong RY, Yong QH, Lew CCY, Hor JW, Tay YW, Zulkefli J, Khairul Anuar AN, Ding HX, Schee JP, Beh YY, Ibrahim KA, Mawardi AS, Lim TT, Looi I, Chia YK, Ooi JCE, Law WC, Wong SC, Lau YH, Teh PC, Ong TL, Cheah WK, Sammler E, Padmanabhan S, Lit LC, Tan EK, Ahmad-Annuar A, Lim SY, Tan AH.

NPJ Parkinsons Dis · 2025-11-18

DOI: 10.1038/s41531-025-01166-xPMID: 41253790

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
Open access

Lack of epistatic interaction of <i>SNCA</i> with <i>APOE</i> in synucleinopathies.

Saini P, Yu E, Estiar MA, Krohn L, Mufti K, Rudakou U, Ruskey JA, Asayesh F, Laurent SB, Spiegelman D, Arnulf I, Montplaisir JY, Gagnon JF, Desautels A, Dauvilliers Y, Gigli GL, Valente M, Janes F, Bernardini A, Šonka K, Kemlink D, Oertel WH, Kaivola K, Janzen A, Plazzi G, Antelmi E, Biscarini F, Figorilli M, Puligheddu M, Mollenhauer B, Trenkwalder C, Sixel-Döring F, Cochen De Cock V, Monaca CC, Heidbreder A, Ferini-Strambi L, Dijkstra F, Viaene M, Abril B, Boeve BF, Postuma RB, Rouleau GA, Anselmi V, Ibrahim A, Stefani A, Högl B, Hu MTM, Scholz SW, Gan-Or Z.

Brain Commun · 2025-11-17

DOI: 10.1093/braincomms/fcaf455PMID: 41341545

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
Open access

Dysregulated proteostasis in p.A53T-α-Synuclein astrocytes aggravates Lewy-like neuropathology in a Parkinson's disease iPSC model.

Paschou C, Apokotou O, Charmpi K, Kollias A, Dede S, Samiotaki M, Koutsoudaki PN, Havaki S, Palese F, Dimoula K, Emmanouilidou E, Gorgoulis VG, Taoufik E, Zurzolo C, Matsas R, Papastefanaki F.

Proc Natl Acad Sci U S A · 2025-11-17

DOI: 10.1073/pnas.2505240122PMID: 41248289

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
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Discovery and optimization of pyrrolopyrimidines as highly potent, selective and brain-penetrant LRRK2 inhibitors.

Axten JM, Ding X, Stasi LP, Zhao B, Sang Y, Ho MH, Wang L, Zhang M, Guo X, Tan C, Feng X, Edge C, Valko K, Li Y, Dong K, Guan X, Zinn N, David Tattersall F, Ren F, Su DS, Reith AD.

RSC Med Chem · 2025-11-17

DOI: 10.1039/d5md00856ePMID: 41393202

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
Source record

CSF α-Synuclein Seed Amplification Assays and Alzheimer Disease Biomarkers in Dementia With Lewy Bodies: Presentation and Progression.

Coughlin DG, Jain L, Khrestian M, Bozoki AC, Galvin JE, Irwin DJ, Lippa CF, Litvan I, Pillai JA, Tousi B, Lopez OL, Berman S, Tsuang DW, Zabetian CP, Fleisher JE, Taylor AS, Leverenz JB, Bekris LM, Galasko D, Dementia With Lewy Bodies Consortium.

Neurology · 2025-11-17

DOI: 10.1212/wnl.0000000000214346PMID: 41248454

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.

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