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Update on the functional biology of Lrrk2.

Melrose H.

Future Neurol · 2008-01-01

DOI: 10.2217/14796708.3.6.669PMID: 19225574

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Noninvasive measurement of protein aggregation by mutant huntingtin fragments or alpha-synuclein in the lens.

Muchowski PJ, Ramsden R, Nguyen Q, Arnett EE, Greiling TM, Anderson SK, Clark JI.

J Biol Chem · 2007-12-31

DOI: 10.1074/jbc.m709678200PMID: 18167346

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The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis.

Gitler AD, Bevis BJ, Shorter J, Strathearn KE, Hamamichi S, Su LJ, Caldwell KA, Caldwell GA, Rochet JC, McCaffery JM, Barlowe C, Lindquist S.

Proc Natl Acad Sci U S A · 2007-12-27

DOI: 10.1073/pnas.0710685105PMID: 18162536

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Genetic variability in the SNCA gene influences alpha-synuclein levels in the blood and brain.

Fuchs J, Tichopad A, Golub Y, Munz M, Schweitzer KJ, Wolf B, Berg D, Mueller JC, Gasser T.

FASEB J · 2007-12-27

DOI: 10.1096/fj.07-9348comPMID: 18162487

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A study of LRRK2 mutations and Parkinson's disease in Brazil.

Pimentel MM, Moura KC, Abdalla CB, Pereira JS, de Rosso AL, Nicaretta DH, Campos M, de Almeida RM, dos Santos JM, Bastos IC, Mendes MF, Maultasch H, Costa FH, Werneck AL, Santos-Rebouças CB.

Neurosci Lett · 2007-12-23

DOI: 10.1016/j.neulet.2007.12.033PMID: 18201824

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RNA interference of LRRK2-microarray expression analysis of a Parkinson's disease key player.

Häbig K, Walter M, Poths S, Riess O, Bonin M.

Neurogenetics · 2007-12-21

DOI: 10.1007/s10048-007-0114-0PMID: 18097693

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Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease.

Orimo S, Uchihara T, Nakamura A, Mori F, Kakita A, Wakabayashi K, Takahashi H.

Brain · 2007-12-13

DOI: 10.1093/brain/awm302PMID: 18079166

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Programmed cell death and new discoveries in the genetics of parkinsonism.

Burke RE.

J Neurochem · 2007-12-10

DOI: 10.1111/j.1471-4159.2007.05106.xPMID: 17996022

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Monoubiquitylation of alpha-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells.

Rott R, Szargel R, Haskin J, Shani V, Shainskaya A, Manov I, Liani E, Avraham E, Engelender S.

J Biol Chem · 2007-12-10

DOI: 10.1074/jbc.m704809200PMID: 18070888

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Ubiquitination of alpha-synuclein by Siah-1 promotes alpha-synuclein aggregation and apoptotic cell death.

Lee JT, Wheeler TC, Li L, Chin LS.

Hum Mol Genet · 2007-12-07

DOI: 10.1093/hmg/ddm363PMID: 18065497

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Mutations in LRRK2 as a cause of Parkinson's disease.

Giasson BI, Van Deerlin VM.

Neurosignals · 2007-12-05

DOI: 10.1159/000109764PMID: 18097165

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An scFv intrabody against the nonamyloid component of alpha-synuclein reduces intracellular aggregation and toxicity.

Lynch SM, Zhou C, Messer A.

J Mol Biol · 2007-12-05

DOI: 10.1016/j.jmb.2007.11.096PMID: 18237741

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