15.097 articles found

Olfactory proteomics reveals the capacity of the HDAC1 inhibitor pyroxamide to halt the α-synuclein preformed fibrils-induced damage in nasal epithelial, microglial and dopaminergic neuronal cell lines

Cartas-Cejudo P, De Miguel M, Extramiana L, Lachén-Montes M, Romero-Murillo S, Gveric D, Fernández-Irigoyen J, Santamaria E.

· 2025-10-03

DOI: 10.1101/2025.10.02.679944

Rotenone accelerates endogenous α-synuclein spreading and enhances neurodegeneration in an intra-striatal α-synuclein preformed fibril injected mouse model of Parkinson's disease.

Khan E, Radwan N, Ardah MT, Kitada T, Haque ME.

Front Cell Neurosci · 2025-10-03

DOI: 10.3389/fncel.2025.1624593PMID: 41114126

Genetic changes in regulatory immune cells induced by pramipexole and rotigotine: implications for the treatment of Parkinson's disease.

Álvarez-Luquín DD, Guevara-Salinas A, Sevilla-Reyes E, Rosas-García J, Bravo-Martinez M, Pérez-Figueroa GE, Vega-Angeles VT, Díaz-Rivera D, Castellanos-Barba C, Adalid-Peralta L.

Inflammopharmacology · 2025-10-03

DOI: 10.1007/s10787-025-01949-xPMID: 41042499

HMGCR genetic variability in Parkinson's disease in a Spanish cohort: associations with lipid metabolism and early onset.

Díaz-Belloso R, Martín-Bornez M, Macías-García D, García-Díaz S, Bonilla-Toribio M, Buiza-Rueda D, Sánchez RP, Muñoz-Delgado L, Ojeda E, Jesús S, Adarmes-Gómez A, Carrillo F, Mir P, Gómez-Garre P.

J Neurol · 2025-10-02

DOI: 10.1007/s00415-025-13404-6PMID: 41037108

Synthetic azo dye amaranth disrupts neuronal plasticity causing alpha-synuclein aggregation and cognitive disability in an in vivo zebrafish model

Gopi S, Prethiba S, Madesh S, Almutairi BO, Choi KC, Arockiaraj J.

Food and Chemical Toxicology · 2025-10-01

Exploring the relationship between <i>GBA1</i> host genotype and gut microbiome in the <i>GBA1</i> <sup>L444P/WT</sup> mouse model: implications for Parkinson's disease pathogenesis.

Menozzi E, Geiger M, Meslier V, Fierli F, Gilles M, Chau KY, David A, Shahar Golan R, Famechon A, Koletsi S, Morabito C, Quinquis B, Pons N, Ehrlich SD, Macnaughtan J, Almeida M, Schapira AH.

Front Neurosci · 2025-10-01

DOI: 10.3389/fnins.2025.1546203PMID: 41103722

Genetic code expansion and enzymatic modifications as accessible methods for studying site-specific post-translational modifications of alpha-synuclein and tau.

Saleh IG, Shimogawa M, Ramirez J, Abakah B, Venkatesh Y, James HP, Li MH, Louie SA, Lougee MG, Chia WK, Brue C, Cooley RB, Mehl RA, Baumgart T, Mach RH, Eliezer D, Rhoades E, Petersson EJ.

Protein Sci · 2025-10-01

DOI: 10.1002/pro.70302PMID: 40944447

Competing chaperone pathways in α-synuclein disaggregation and aggregation dynamics.

Auld NK, McMahon S, Marzano NR, van Oijen AM, Ecroyd H.

Protein Sci · 2025-10-01

DOI: 10.1002/pro.70296PMID: 40944457

Targeting specific kinase substrates rescues increased colitis severity induced by the Crohn's disease-linked LRRK2-N2081D variant.

Heaton GR, Li X, Li X, Zhou X, Zhang Y, Vu DT, Oeller M, Karayel O, Hoang QQ, Kars ME, Kamath N, Wang M, Tarassishin L, Mann M, Peter I, Yue Z.

J Clin Invest · 2025-10-01

DOI: 10.1172/jci190017PMID: 41031878

Severe GBA1 variants drive the GBA1-PD clinical phenotype: implications for counselling and clinical trials.

Menozzi E, Del Pozo SL, Macnaughtan J, Mezabrovschi R, Koletsi S, Mitrotti P, Gallo L, Calabrese R, Toffoli M, Loefflad N, Valzania F, Cavallieri F, Fioravanti V, Yalkic S, Limbachiya N, Blandini F, Avenali M, Schapira AH.

NPJ Parkinsons Dis · 2025-10-01

DOI: 10.1038/s41531-025-01063-3PMID: 41034226

Alpha- and Gamma-Synucleins Regulate Energy Metabolism and Xanthine Oxidase Activity in Brain Cells.

Fedulina AA, Seryogina ES, Krayushkina AM, Chaprov KD, Vinokurov AY, Abramov AY.

Biochemistry (Mosc) · 2025-10-01

DOI: 10.1134/s0006297925602278PMID: 41176797

α-Synuclein seed amplification assay in Lewy body dementia versus Alzheimer's disease.

McWilliam OH, Bsoul R, Lund EL, Waldemar G, Hasselbalch SG, Simonsen AH, Bruun M, von Buchwald C, Aanæs K, Pedersen CK, Andersen ISB, Bech M, Areškevičiūtė A, Frederiksen KS.

Alzheimers Dement (Amst) · 2025-10-01

DOI: 10.1002/dad2.70203PMID: 41211301