14.936 articles found

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders.

Masliah E, Rockenstein E, Veinbergs I, Mallory M, Hashimoto M, Takeda A, Sagara Y, Sisk A, Mucke L.

Science · 2000-02-01

DOI: 10.1126/science.287.5456.1265PMID: 10678833

A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease.

Giasson BI, Jakes R, Goedert M, Duda JE, Leight S, Trojanowski JQ, Lee VM.

J Neurosci Res · 2000-02-01

DOI: 10.1002/(sici)1097-4547(20000215)59:4<528::aid-jnr8>3.0.co;2-0PMID: 10679792

The emerging field of ecogenetics.

Costa LG.

Neurotoxicology · 2000-02-01

PMID: 10794388

[Respiratory function impairment in patients with Parkinson's disease--a consideration on the possible pathogenetic relation to autonomic dysfunction].

Yamada H, Murahashi M, Takahashi H, Kai K, Shibuya S, Jimi T, Wakayama Y, Yamada M.

Rinsho Shinkeigaku · 2000-02-01

PMID: 10835931

Research advances on the genetics of Parkinson^s disease

Liang Xibin, Wang Xiaomin.

Chinese Bulletin of Life Sciences · 2000-01-01

Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein.

Okochi M, Walter J, Koyama A, Nakajo S, Baba M, Iwatsubo T, Meijer L, Kahle PJ, Haass C.

J Biol Chem · 2000-01-01

DOI: 10.1074/jbc.275.1.390PMID: 10617630

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy.

Conway KA, Lee SJ, Rochet JC, Ding TT, Williamson RE, Lansbury PT.

Proc Natl Acad Sci U S A · 2000-01-01

DOI: 10.1073/pnas.97.2.571PMID: 10639120

The EcoRV genetic polymorphism of human monoamine oxidase type A is not associated with Parkinson's disease and does not modify the effect of smoking on Parkinson's disease.

Costa-Mallen P, Checkoway H, Fishel M, Cohen AW, Smith-Weller T, Franklin GM, Swanson PD, Costa LG.

Neurosci Lett · 2000-01-01

DOI: 10.1016/s0304-3940(99)00890-3PMID: 10643794

NACP/alpha-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson's disease brains.

Wakabayashi K, Hayashi S, Yoshimoto M, Kudo H, Takahashi H.

Acta Neuropathol · 2000-01-01

DOI: 10.1007/pl00007400PMID: 10651022

A kindred with Parkinson's disease not showing genetic linkage to established loci.

Gwinn-Hardy KA, Crook R, Lincoln S, Adler CH, Caviness JN, Hardy J, Farrer M.

Neurology · 2000-01-01

DOI: 10.1212/wnl.54.2.504PMID: 10668726

MPTP induces alpha-synuclein aggregation in the substantia nigra of baboons.

Kowall NW, Hantraye P, Brouillet E, Beal MF, McKee AC, Ferrante RJ.

Neuroreport · 2000-01-01

DOI: 10.1097/00001756-200001170-00041PMID: 10683860

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system.

Abeliovich A, Schmitz Y, Fariñas I, Choi-Lundberg D, Ho WH, Castillo PE, Shinsky N, Verdugo JM, Armanini M, Ryan A, Hynes M, Phillips H, Sulzer D, Rosenthal A.

Neuron · 2000-01-01

DOI: 10.1016/s0896-6273(00)80886-7PMID: 10707987