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“Parkinson LRRK2” Clear search

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Dopamine D2 receptor upregulation in dorsal striatum in the LRRK2-R1441C rat model of early Parkinson's disease revealed by in vivo PET imaging.

Delgado-Goñi T, Connor-Robson N, Cioroch M, Paisey S, Marshall C, Lane EL, Hauton D, McCullagh J, Magill PJ, Cragg SJ, Mackay CE, Wade-Martins R, Klein JC.

Sci Rep · 2025-05-07

DOI: 10.1038/s41598-025-99580-xPMID: 40335575

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
Open access

Emergent glutamate & dopamine dysfunction in VPS35<sub>(D620N)</sub> knock-in mice and rapid reversal by LRRK2 inhibition.

Kamesh A, Kadgien CA, Kuhlmann N, Coady S, Pietrantonio A, Cousineau Y, Khayachi A, Jurado Santos A, Hurley EP, Barron JC, Parsons MP, Milnerwood AJ.

NPJ Parkinsons Dis · 2025-05-03

DOI: 10.1038/s41531-025-00948-7PMID: 40319043

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
Open access

LRRK2 rare-variant per-domain genetic burden in Parkinson's Disease: association confined to the kinase domain.

Parlar SC, Senkevich K, Yu E, Ruskey JA, Ahmad J, Asayesh F, Spiegelman D, Waters C, Monchi O, Dauvilliers Y, Dupré N, Greenbaum L, Hassin-Baer S, Miliukhina I, Timofeeva A, Emelyanov A, Pchelina S, Alcalay RN, Fon EA, Trempe JF, Gan-Or Z.

NPJ Parkinsons Dis · 2025-04-29

DOI: 10.1038/s41531-025-00934-zPMID: 40301370

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
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Lysosomal TPC2 channels disrupt Ca2+ entry and dopaminergic function in models of LRRK2-Parkinson's disease.

Gregori M, Pereira GJS, Allen R, West N, Chau KY, Cai X, Bostock MP, Bolsover SR, Keller M, Lee CY, Lei SH, Harvey K, Bracher F, Grimm C, Hasan G, Gegg ME, Schapira AHV, Sweeney ST, Patel S.

J Cell Biol · 2025-04-25

DOI: 10.1083/jcb.202412055PMID: 40279672

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
Open access

The Leucine-Rich Repeat Kinase 2 Variant LRRK2<sup>G2019S</sup> Up-Regulates L-Type (CaV1.3) Calcium Channel via the Ca<sub>V</sub>β<sub>3</sub> Subunit: Possible Role in the Pathogenesis of Parkinson's Disease.

Sandoval A, Corzo-López A, Duran P, Tovar-Soto D, Vargas-Caballero B, Galicia-Saldaña V, González-Ramírez R, Felix R.

Int J Mol Sci · 2025-03-31

DOI: 10.3390/ijms26073229PMID: 40244042

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.

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