1.289 articles found

A Structural Proteomics Exploration of Synphilin-1 and Alpha-Synuclein Interaction in Pathogenesis of Parkinson's Disease.

Tripathi A, Mondal R, Mandal M, Lahiri T, Pal MK.

Biomolecules · 2024-12-12

DOI: 10.3390/biom14121588PMID: 39766295

Taurine, an essential amino acid, attenuates rotenone-induced Parkinson's disease in rats by inhibiting alpha-synuclein aggregation and augmenting dopamine release.

Onuelu JE, Ben-Azu B, Adebayo OG, Fokoua AR, Nekabari MK, Ozah EO, Iwhiwhu P, Ajayi AM, Oyovwi OM, Omogbiy IA, Eduviere AT, Ojezele MO.

Behav Brain Res · 2024-12-12

DOI: 10.1016/j.bbr.2024.115397PMID: 39674372

Intranasal administration of tissue inhibitor of metalloproteinase 1 extracted from stem cells from human exfoliated deciduous teeth-conditioned medium improves neurological outcomes and alpha-synuclein elimination in Parkinson's disease mice.

Chen YN, Chen YR, Yang BH, Lee PH, Kuo LT, Li CH.

J Dent Sci · 2024-12-12

DOI: 10.1016/j.jds.2024.11.029PMID: 40224104

Exploring Cimetidine as a Potential Therapeutic Attenuator against Amyloid Formation in Parkinson's Disease: Spectroscopic and Microscopic Insights into Alpha-Synuclein and Human Insulin.

Hassan MN, Ahmad A, Hussain M, Gupta S, Khan HY, Aziz T, Khan RH.

ACS Chem Neurosci · 2024-12-04

DOI: 10.1021/acschemneuro.4c00588PMID: 39628315

Autoantibody profiles in Alzheimer´s, Parkinson´s, and dementia with Lewy bodies: altered IgG affinity and IgG/IgM/IgA responses to alpha-synuclein, amyloid-beta, and tau in disease-specific pathological patterns.

Knecht L, Dalsbøl K, Simonsen AH, Pilchner F, Ross JA, Winge K, Salvesen L, Bech S, Hejl AM, Løkkegaard A, Hasselbalch SG, Dodel R, Aznar S, Waldemar G, Brudek T, Folke J.

J Neuroinflammation · 2024-12-03

DOI: 10.1186/s12974-024-03293-3PMID: 39627772

Autophagy Deficits Underly Selective Neuronal Vulnerability to Alpha Synuclein Fibrils in Alzheimer’s and Parkinson’s iPSC Derived Neurons

Abey A, Ng B, Heon‐Roberts R, Carlyle B, Bengoa‐Vergniory N, Wade‐Martins R.

Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024-12-01

Characterization and Evaluation of Alpha‐Synuclein Aggregates: Unveiling Their Potential as a Biomarker for Parkinson's Disease (PD)

Debarnot C, Challagundla M, Kleinert C, Schulz M, Henn C, Boehm N, Richter M.

Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024-12-01

Serum Alpha‐Synuclein and Inflammatory Markers profile in an Egyptian Alzheimer’s and Parkinson’s Diseases patients: A Pilot Study

Heikal S.

Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024-12-01

MJF-14 proximity ligation assay detects early non-inclusion alpha-synuclein pathology with enhanced specificity and sensitivity.

Jensen NM, Fu Y, Betzer C, Li H, Elfarrash S, Shaib AH, Krah D, Vitic Z, Reimer L, Gram H, Buchman V, Denham M, Rizzoli SO, Halliday GM, Jensen PH.

NPJ Parkinsons Dis · 2024-11-29

DOI: 10.1038/s41531-024-00841-9PMID: 39613827

Alpha-Synuclein and Microglia in Parkinson's Disease: From Pathogenesis to Therapeutic Prospects.

Eo H, Kim S, Jung UJ, Kim SR.

J Clin Med · 2024-11-28

DOI: 10.3390/jcm13237243PMID: 39685702

Alpha-synuclein Fibrils Inhibit Activation of the BDNF/ERK Signaling Loop in the mPFC to Induce Parkinson's Disease-like Alterations with Depression.

Ma Z, Xu Y, Lian P, Wu Y, Liu K, Zhang Z, Tang Z, Yang X, Cao X.

Neurosci Bull · 2024-11-28

DOI: 10.1007/s12264-024-01323-xPMID: 39609371

The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons.

Jones-Tabah J, He K, Karpilovsky N, Senkevich K, Deyab G, Pietrantonio I, Goiran T, Cousineau Y, Nikanorova D, Goldsmith T, Del Cid Pellitero E, Chen CX, Luo W, You Z, Abdian N, Ahmad J, Ruskey JA, Asayesh F, Spiegelman D, Fahn S, Waters C, Monchi O, Dauvilliers Y, Dupré N, Miliukhina I, Timofeeva A, Emelyanov A, Pchelina S, Greenbaum L, Hassin-Baer S, Alcalay RN, Milnerwood A, Durcan TM, Gan-Or Z, Fon EA.

Mol Neurodegener · 2024-11-25

DOI: 10.1186/s13024-024-00779-9PMID: 39587654