1.241 articles found

The LRRK2 p.L1795F variant causes Parkinson's disease in the European population.

Lange LM, Levine K, Fox SH, Marras C, Ahmed N, Kuznetsov N, Vitale D, Iwaki H, Lohmann K, Marsili L, Espay AJ, Bauer P, Beetz C, Martin J, Factor SA, Higginbotham LA, Chen H, Leonard H, Nalls MA, Mencacci NE, Morris HR, Singleton AB, Klein C, Blauwendraat C, Fang ZH, Global Parkinson’s Genetics Program (GP2).

NPJ Parkinsons Dis · 2025-03-25

DOI: 10.1038/s41531-025-00896-2PMID: 40133296

Prevalence and Clinical Characteristics of the LRRK2 p.L1795F Variant in Central Europeans with Early-Onset and Familial Parkinson's Disease.

Ostrozovicova M, Tamas G, Atputhavadivel A, Dusek P, Grofik M, Han V, Holly P, Jech R, Kalinova K, Klivenyi P, Kovacs N, Kulcsarova K, Kurca E, Lackova A, Lee H, Lewis P, Magocova V, Marekova M, Murphy D, Nagano A, Necpal J, Pinter D, Rabajdova M, Ruzicka E, Serranova T, Smilowska K, Soos K, Straka I, Svorenova T, Valkovic P, Zarubova K, Gdovinova Z, Houlden H, Rizig M, Skorvanek M, CEGEMOD consortium.

Mov Disord Clin Pract · 2025-03-22

DOI: 10.1002/mdc3.70045PMID: 40119633

<i>LRRK2</i>-associated parkinsonism with and without <i>in vivo</i> evidence of alpha-synuclein aggregates: longitudinal clinical and biomarker characterization.

Chahine LM, Lafontant DE, Choi SH, Iwaki H, Blauwendraat C, Singleton AB, Brumm MC, Alcalay RN, Merchant K, Nudelman KNH, Dagher A, Vo A, Tao Q, Venuto CS, Kieburtz K, Poston KL, Bressman S, Gonzalez-Latapi P, Avants B, Coffey C, Jennings D, Tolosa E, Siderowf A, Marek K, Simuni T, Parkinson’s Progression Markers Initiative .

Brain Commun · 2025-03-06

DOI: 10.1093/braincomms/fcaf103PMID: 40114783

LRRK2 in Drosophila Melanogaster Model: Insights into Cellular Dysfunction and Neuroinflammation in Parkinson's Disease.

Ciampelli C, Galleri G, Galioto M, Mereu P, Pirastru M, Bernardoni R, Albani D, Crosio C, Iaccarino C.

Int J Mol Sci · 2025-02-27

DOI: 10.3390/ijms26052093PMID: 40076730

Clinical and functional evidence for the pathogenicity of the LRRK2 p.Arg1067Gln variant.

Lim SY, Toh TS, Hor JW, Lim JL, Lit LC, Ahmad-Annuar A, Tay YW, Foo JN, Ng EY, Muthusamy KA, Mohamed Ibrahim N, Ibrahim KA, Tan LCS, Zulkefli J, Khairul Anuar AN, Black K, Lis P, Xie F, Cen Z, Lim KS, Lohmann K, Padmanabhan S, Alessi DR, Luo W, Tan EK, Sammler E, Tan AH.

NPJ Parkinsons Dis · 2025-02-23

DOI: 10.1038/s41531-025-00884-6PMID: 39988587

LRRK2, lysosome damage, and Parkinson's disease.

Bentley-DeSousa A, Clegg D, Ferguson SM.

Curr Opin Cell Biol · 2025-02-20

DOI: 10.1016/j.ceb.2025.102482PMID: 39983584

Heartbeat signature for predicting motor and non-motor involvement among nonparkinsonian LRRK2 G2019S mutation carriers.

Carricarte Naranjo C, Marras C, Visanji NP, Cornforth DJ, Sanchez-Rodriguez L, Schüle B, Goldman SM, Estévez M, Stein PK, Jelinek HF, Lang AE, Machado A.

Clin Auton Res · 2025-02-19

DOI: 10.1007/s10286-024-01104-6PMID: 39969690

Updated MDSGene review on the clinical and genetic spectrum of LRRK2 variants in Parkinson´s disease.

Krüger C, Lim SY, Buhrmann A, Fahrig FL, Gabbert C, Bahr N, Madoev H, Marras C, Klein C, Lohmann K.

NPJ Parkinsons Dis · 2025-02-17

DOI: 10.1038/s41531-025-00881-9PMID: 39962078

Using computer modeling to find new LRRK2 inhibitors for parkinson's disease.

García MC, Cuesta SA, Mora JR, Paz JL, Marrero-Ponce Y, Alexis F, Márquez EA.

Sci Rep · 2025-02-03

DOI: 10.1038/s41598-025-86926-8PMID: 39900949

A150 THE PARKINSON’S DISEASE-ASSOCIATED MUTATION LRRK2 G2019S INCITES NEUTROPHILIC INFLAMMATION AND INCREASED TISSUE DAMAGE IN A MOUSE MODEL OF INFECTIOUS COLITIS.

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Journal of the Canadian Association of Gastroenterology · 2025-02-01

Clinico-genetic analysis of patients with LRRK2-related Parkinson's disease from a referral centre in India.

Rath S, Holla VV, Phulpagar P, Kamath SD, Kamble N, Muthusamy B, Yadav R, Pal PK.

Parkinsonism Relat Disord · 2025-01-27

DOI: 10.1016/j.parkreldis.2025.107299PMID: 39904175

Unraveling Hormonal Influence of Menstrual Cycle in a Young Patient with LRRK2-Parkinson's Disease.

Ferreira F, Correia C, Soares C.

Mov Disord Clin Pract · 2025-01-21

DOI: 10.1002/mdc3.14337PMID: 39835616