20.648 articles found

Next-generation CRISPR gene editing tools in the precision treatment of Alzheimer's and Parkinson's disease.

Meshram HK, Gupta SK, Gupta A, Nagori K, Ajazuddin.

Ageing Res Rev · 2025-08-05

DOI: 10.1016/j.arr.2025.102851PMID: 40752775

Synthesis and evaluation of novel 5-HT<sub>2A</sub> receptor inverse agonist with excellent in vivo antipsychotic efficacy and superior tissue distribution for treatment of Parkinson's disease psychosis.

Ma M, Du G, Wang W, Dai Y, Xu H, Wei Y, Yang H, Zhu X, Zhao M, Gao Y, Zhang J, Ye L, Tian J.

Eur J Med Chem · 2025-08-05

DOI: 10.1016/j.ejmech.2025.118044PMID: 40784305

Targeting pantothenate kinases in human diseases: Biochemistry and pharmacotherapy.

Zhang X, Zhang B, Li X, Qiu F, Zhang Q, Kang N.

Biochem Pharmacol · 2025-08-05

DOI: 10.1016/j.bcp.2025.117207PMID: 40754168

Is the renin-angiotensin system a friend or foe in neurological diseases? Unveiling its role and therapeutic potential.

Porel P, Hunjan G, Singh S, Aran KR.

Ageing Res Rev · 2025-08-05

DOI: 10.1016/j.arr.2025.102854PMID: 40763898

Targeting the Dectin-1 Receptor in Neuroinflammation: Therapeutic Implications for Neuropsychiatric Disorders.

Nascimento EFD, Batista PVC, Cunha CS, Lacerda LRA, Moura VC, Oliveira TQ, Filho AJMC, de Rezende PHF, Macedo DS, Vasconcelos SMM.

ACS Chem Neurosci · 2025-08-04

DOI: 10.1021/acschemneuro.5c00221PMID: 40758965

Clinical efficacy of GLP-1 receptor agonists in the treatment of Parkinson's disease: a systematic review and meta-analysis of randomized controlled trials.

Zhang Y, Wang C, Wang Y, Wang T.

J Neurol · 2025-08-04

DOI: 10.1007/s00415-025-13301-yPMID: 40760123

Efficacy of cholinesterase inhibitors and memantine on symptoms not responsive to levodopa in patients affected by Parkinson's disease without dementia: a systematic review.

Cani I, Grotteschi N, Calandra-Buonaura G, Guarino M, Guaraldi P, Giannini G, Baldelli L, Donati M, Cortelli P, Camerlingo MD, Nonino F, Sambati L.

BMJ Neurol Open · 2025-08-03

DOI: 10.1136/bmjno-2025-001079PMID: 40761830

Oxidative Stress in DNA Damage and Neurodegenerative Diseases: Unveiling The Mechanisms and Therapeutic Opportunities.

Rahman MA, Khatun MT, Mim AK, Khandocar MP, Rahman A, Hasan MH, Shimki AI, Hossain MS, Shoily MSA, Faraque A, Amin MF, Ferdous R, Islam MS.

Cell Biochem Biophys · 2025-08-02

DOI: 10.1007/s12013-025-01845-9PMID: 40751885

Therapeutic potential of lipids of Irish marine cyanobacteria Chlorogloea microcystoides SABC 022904 and Phormidium africanum SABC 022001

Shiels K, Silva J, Alves C, Pedrosa R, Murray P, Saha SK.

Journal of functional foods · 2025-08-01

Targeting ferroptosis and mitophagy with neutrophil-inspired nanozyme for Parkinson's disease therapy

Tian Y, Wang F, Ma J, Huang W, Zhang X, Du C, Wei P, Huang W, Zhu Y, Lin Y.

Journal of Controlled Release · 2025-08-01

Shared pathogenic mechanisms of Parkinson's disease and ulcerative colitis: α7 nicotinic acetylcholine receptor as a potential therapeutic target

Li Y, Gu Y, Li J, Liu F, Chen H, Hou H, Hu Q.

International Journal of Biological Macromolecules · 2025-08-01

194. RISK OF AGRANULOCYTOSIS AND NEUTROPENIA IN PATIENTS WITH PARKINSON'S DISEASE PSYCHOSIS RECEIVING CLOZAPINE TREATMENT: A SYSTEMATIC REVIEW AND META-ANALYSIS

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The international journal of neuropsychopharmacology · 2025-08-01