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Calcium at the crossroads: TPC2's role in LRRK2-linked Parkinson's disease.

De Lazzari F, Wanderoy S, Whitworth AJ.

Cell Calcium · 2025-06-17

DOI: 10.1016/j.ceca.2025.103049PMID: 40570679

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Minimally invasive upconversion optogenetics for Parkinson's disease treatment.

Li X, Wang X, Zhou T, Yu J, Xiang H, Zhang C, Sun SK, Liu R.

Biomaterials · 2025-06-17

DOI: 10.1016/j.biomaterials.2025.123509PMID: 40541087

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Open access

Development of Positron Emission Tomography Radiotracers for Imaging α-Synuclein Aggregates.

Guo X, Xiang J, Ye K, Zhang Z.

Cells · 2025-06-16

DOI: 10.3390/cells14120907PMID: 40558534

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Poly-γ-glutamic acid alleviates cytotoxicity and inflammation induced by pre-formed fibrils of α-synuclein in murine primary astrocytes.

Novello C, Parati M, Mazzetti S, Rampoldi O, Isilgan HB, Basellini MJ, De Luca CMG, Ciullini A, Dellarole IL, Fantin A, Russo I, Johnston BL, Paroni M, Rolando C, Moda F, Pezzoli G, Radecka IK, Cappelletti G.

Int J Biol Macromol · 2025-06-16

DOI: 10.1016/j.ijbiomac.2025.145303PMID: 40533008

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Open access

Detecting alpha-synuclein aggregates with small molecules on single-molecule array.

Lam JYL, Chisholm TS, Almahli H, English EA, Xia Z, Wu Y, Cheetham MR, Hunter CA, Klenerman D.

Chem Sci · 2025-06-16

DOI: 10.1039/d4sc07649dPMID: 40584232

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Open access

Blood α-Synuclein Separates Parkinson's Disease from Dementia with Lewy Bodies.

Kannarkat GT, Zack R, Skrinak RT, Morley JF, Davila-Rivera R, Arezoumandan S, Dorfman K, Luk K, Wolk DA, Weintraub D, Tropea TF, Lee EB, Xie SX, Chandrasekaran G, Lee VM, Irwin D, Akhtar RS, Chen-Plotkin AS.

Ann Neurol · 2025-06-16

DOI: 10.1002/ana.27288PMID: 40521808

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Open access

Evaluation, Diagnosis, and Treatment of Concomitant Movement Disorders in Genetic Epilepsies.

Garris J, Abbott M, Axeen E, Tochen L, Schreiber JM.

Epilepsy Curr · 2025-06-16

DOI: 10.1177/15357597251323917PMID: 40534755

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Dissecting the biological impact of <i>GBA1</i> mutations using multi-omics in an isogenic setting

Jerez PÁ, Wild Crea PA, Patel D, Glasstetter LM, Alvarez C, Makarious MB, Lara E, Chen Y, Pantazis CB, Paquette K, Malik L, Nalls MA, Reed X, Singleton AB, Billingsley KJ, Mcdonough JA, Ning G, Skarnes WC, Ryten M, Sidransky E, Cookson MR, Beilina S, Blauwendraat C.

· 2025-06-15

DOI: 10.1101/2025.06.12.656971

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Modulation of SLP-2 expression protects against alpha-synuclein neuropathology by mitigating mitochondrial dysfunction

Bolduc C, Castelo Rueda MP, Lorente Picón M, Gentile G, Kalvakuri S, Linan VS, Zanon A, Laouafa S, Lang M, Lavdas AA, Gilmozzi V, Bernardo G, Coulombe V, Gora C, Peralta MR, Rioux V, Honisch C, Pramstaller PP, Ruzza P, Ziviani E, Bodmer R, Hicks AA, Parent M, Soliz J, Joseph V, Pichler I, Levesque M.

· 2025-06-15

DOI: 10.1101/2025.06.13.659577

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Open access

A mechanistic model of pure and lipidic α-synuclein aggregation for advancing Parkinson's therapies.

Righetti E, Marchetti L, Domenici E, Reali F.

Commun Chem · 2025-06-14

DOI: 10.1038/s42004-025-01558-3PMID: 40517155

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Open access

Structural biology of Parkinson's disease-associated leucine-rich repeat kinase 2 (LRRK2).

Leschziner AE.

J Biol Chem · 2025-06-14

DOI: 10.1016/j.jbc.2025.110376PMID: 40523620

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Regulation of LRRK2 activity by metabolic stress and heavy metal exposure.

Kentros M, Follett J, Subrahmanian N, Chairmandurai A, Melachroinou K, Re DB, de Cabo R, Chia R, Kluss JH, Beilina A, Mortiboys H, LaVoie MJ, Rideout HJ, Cookson MR, Mamais A.

Brain Res · 2025-06-14

DOI: 10.1016/j.brainres.2025.149785PMID: 40523461

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Records come from scientific sources. Bibliographic counts do not represent completed translations or editorial approvals.

15.097 articles found

Calcium at the crossroads: TPC2's role in LRRK2-linked Parkinson's disease.

Minimally invasive upconversion optogenetics for Parkinson's disease treatment.

Development of Positron Emission Tomography Radiotracers for Imaging α-Synuclein Aggregates.

Poly-γ-glutamic acid alleviates cytotoxicity and inflammation induced by pre-formed fibrils of α-synuclein in murine primary astrocytes.

Detecting alpha-synuclein aggregates with small molecules on single-molecule array.

Blood α-Synuclein Separates Parkinson's Disease from Dementia with Lewy Bodies.

Evaluation, Diagnosis, and Treatment of Concomitant Movement Disorders in Genetic Epilepsies.

Dissecting the biological impact of <i>GBA1</i> mutations using multi-omics in an isogenic setting

Modulation of SLP-2 expression protects against alpha-synuclein neuropathology by mitigating mitochondrial dysfunction

A mechanistic model of pure and lipidic α-synuclein aggregation for advancing Parkinson's therapies.

Structural biology of Parkinson's disease-associated leucine-rich repeat kinase 2 (LRRK2).

Regulation of LRRK2 activity by metabolic stress and heavy metal exposure.

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