1.296 articles found

The Role of Alpha-Synuclein and Tubulin-Associated Unit (Tau) Proteins in the Diagnosis, Prognosis, and Treatment of Parkinson's Disease: A Systematic Review.

Lin YM, Banoth D, Wali MH, Bekova K, Abdulla N, Gurugubelli S, Khan S.

Cureus · 2024-07-17

DOI: 10.7759/cureus.64766PMID: 39156411

Visualizing alpha-synuclein and iron deposition in M83 mouse model of Parkinson's disease in vivo.

Straumann N, Combes BF, Dean Ben XL, Sternke-Hoffmann R, Gerez JA, Dias I, Chen Z, Watts B, Rostami I, Shi K, Rominger A, Baumann CR, Luo J, Noain D, Nitsch RM, Okamura N, Razansky D, Ni R.

Brain Pathol · 2024-07-09

DOI: 10.1111/bpa.13288PMID: 38982662

Dose-Dependent Alterations of Lysosomal Activity and Alpha-Synuclein in Peripheral Blood Monocyte-Derived Macrophages and SH-SY5Y Neuroblastoma Cell Line by upon Inhibition of MTOR Protein Kinase - Assessment of the Prospects of Parkinson's Disease Therapy.

Bezrukova AI, Basharova KS, Baydakova GV, Zakharova EY, N Pchelina S, Usenko TS.

Biochemistry (Mosc) · 2024-07-01

DOI: 10.1134/s0006297924070113PMID: 39218026

Ion channel dysregulation and cellular adaptations to alpha-synuclein in stressful pacemakers of the parkinsonian brainstem.

Chiu WH, Wattad N, Goldberg JA.

Pharmacol Ther · 2024-06-29

DOI: 10.1016/j.pharmthera.2024.108683PMID: 38950869

Enhancing mitochondrial proteolysis alleviates alpha-synuclein-mediated cellular toxicity.

Zhang X, Ruan L, Wang H, Zhu J, Li T, Sun G, Dong Y, Wang Y, Berreby G, Shay A, Chen R, Ramachandran S, Dawson VL, Dawson TM, Li R.

NPJ Parkinsons Dis · 2024-06-21

DOI: 10.1038/s41531-024-00733-yPMID: 38906862

Alpha-synuclein-induced stress sensitivity renders the Parkinson's disease brain susceptible to neurodegeneration.

Nakos Bimpos M, Karali K, Antoniou C, Palermos D, Fouka M, Delis A, Tzieras I, Chrousos GP, Koutmani Y, Stefanis L, Polissidis A.

Acta Neuropathol Commun · 2024-06-17

DOI: 10.1186/s40478-024-01797-wPMID: 38886854

Alpha-Synuclein Gene Alterations Modulate Tyrosine Hydroxylase in Human iPSC-Derived Neurons in a Parkinson's Disease Animal Model.

Bernal-Conde LD, Peña-Martínez V, Morato-Torres CA, Ramos-Acevedo R, Arias-Carrión Ó, Padilla-Godínez FJ, Delgado-González A, Palomero-Rivero M, Collazo-Navarrete O, Soto-Rojas LO, Gómez-Chavarín M, Schüle B, Guerra-Crespo M.

Life (Basel) · 2024-06-05

DOI: 10.3390/life14060728PMID: 38929711

Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson's patients.

de Boni L, Wallis A, Hays Watson A, Ruiz-Riquelme A, Leyland LA, Bourinaris T, Hannaway N, Wüllner U, Peters O, Priller J, Falkenburger BH, Wiltfang J, Bähr M, Zerr I, Bürger K, Perneczky R, Teipel S, Löhle M, Hermann W, Schott BH, Brockmann K, Spottke A, Haustein K, Breuer P, Houlden H, Weil RS, Bartels T.

EMBO Mol Med · 2024-06-05

DOI: 10.1038/s44321-024-00083-5PMID: 38839930

Alpha-Synuclein Gene Alterations Modulate Tyrosine Hydroxylase in Human iPSC-Derived Neurons in a Parkinson’s Disease Animal Model

Bernal-Conde L, Peña-Martínez V, Morato-Torres C, Ramos-Acevedo R, Arias-Carrión Ó, Padilla-Godínez F, Delgado-González A, Palomero-Rivero M, Collazo-Navarrete O, Soto-Rojas L, Gómez-Chavarín M, Schüle B, Guerra-Crespo M.

Life (Basel, Switzerland) · 2024-06-01

ADVANCEMENT IN ALPHA-SYNUCLEIN PROTEOMICS: EXPLORING ANALYTICAL TECHNIQUES AND THEIR CLINICAL IMPLICATIONS IN PARKINSON'S DISEASE.

Palanisamy S, Subramani P, Narasimman P, Murugesan M.

Georgian Med News · 2024-06-01

PMID: 39230220

Cathepsin-mediated regulation of alpha-synuclein in Parkinson's disease: a Mendelian randomization study.

Lin L, Wu Z, Luo H, Huang Y.

Front Aging Neurosci · 2024-05-30

DOI: 10.3389/fnagi.2024.1394807PMID: 38872630

A stem cell-based assay platform demonstrates alpha-synuclein dependent synaptic dysfunction in patient-derived cortical neurons.

White AJ, Clark KA, Alexander KD, Ramalingam N, Young-Pearse TL, Dettmer U, Selkoe DJ, Ho GPH.

NPJ Parkinsons Dis · 2024-05-21

DOI: 10.1038/s41531-024-00725-yPMID: 38773105