15.286 articles found

High-resolution Cryo-EM Structure Determination of a-Synuclein-A Prototypical Amyloid Fibril.

Sanchez JC, Pierson JA, Borcik CG, Rienstra CM, Wright ER.

Bio Protoc · 2025-02-05

DOI: 10.21769/bioprotoc.5171PMID: 39959285

Fasudil inhibits α-synuclein aggregation through ROCK-inhibition-mediated mechanisms.

Lage L, Rodriguez-Perez AI, Labandeira-Garcia JL, Dominguez-Meijide A.

Neurotherapeutics · 2025-02-05

DOI: 10.1016/j.neurot.2025.e00544PMID: 39915220

Identification of Parkinson's disease using MRI and genetic data from the PPMI cohort: an improved machine learning fusion approach.

Yang Y, Hu L, Chen Y, Gu W, Lin G, Xie Y, Nie S.

Front Aging Neurosci · 2025-02-04

DOI: 10.3389/fnagi.2025.1510192PMID: 39968123

Beyond amyloid plaque, targeting α-synuclein in Alzheimer disease: The battle continues.

Al-Kuraishy HM, Sulaiman GM, Mohammed HA, Al-Gareeb AI, Albuhadily AK, Ali AA, Abu-Alghayth MH.

Ageing Res Rev · 2025-02-04

DOI: 10.1016/j.arr.2025.102684PMID: 39914501

Short-Chain Fatty Acid Aggregates Alpha-Synuclein Accumulation and Neuroinflammation via GPR43-NLRP3 Signaling Pathway in a Model Parkinson's Disease.

Qu Y, An K, Wang D, Yu H, Li J, Min Z, Xiong Y, Xue Z, Mao Z.

Mol Neurobiol · 2025-02-04

DOI: 10.1007/s12035-025-04726-7PMID: 39904963

Chemogenetic Control of Striatal Astrocytes Improves Parkinsonian Motor Deficits in Mice.

Evans WR, Baskar SS, Vellore A, Costa ARCE, Jacob C, Ravoori S, Arigbe A, Huda R.

Glia · 2025-02-04

DOI: 10.1002/glia.24679PMID: 39902809

Biological definitions of synucleinopathies should be anchored in clinical trajectories and encompass the complex biology of the disease.

Bendetowicz D, Planche V, Bezard E, Dehay B, Meissner WG.

J Parkinsons Dis · 2025-02-04

DOI: 10.1177/1877718x241313443PMID: 39973487

Using computer modeling to find new LRRK2 inhibitors for parkinson's disease.

García MC, Cuesta SA, Mora JR, Paz JL, Marrero-Ponce Y, Alexis F, Márquez EA.

Sci Rep · 2025-02-03

DOI: 10.1038/s41598-025-86926-8PMID: 39900949

α-Synuclein Iron-Responsive-Element RNA and Iron Regulatory Protein Affinity Is Specifically Reduced by Iron in Parkinson's Disease.

Khan MA.

Biomolecules · 2025-02-02

DOI: 10.3390/biom15020214PMID: 40001517

Ergothioneine exerts neuroprotective effects in Parkinson’s disease: Targeting α-synuclein aggregation and oxidative stress

Gao W, Wang Y, Wang F, Wu X, Lu F, Liu F.

Food Research International. · 2025-02-01

USP14 is crucial for proteostasis regulation and α-synuclein degradation in human SH-SY5Y dopaminergic cells

Srinivasan V, Soliymani R, Ivanova L, Eriksson O, Peitsaro N, Lalowski M, Karelson M, Lindholm D.

Heliyon · 2025-02-01

A150 THE PARKINSON’S DISEASE-ASSOCIATED MUTATION LRRK2 G2019S INCITES NEUTROPHILIC INFLAMMATION AND INCREASED TISSUE DAMAGE IN A MOUSE MODEL OF INFECTIOUS COLITIS.

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Journal of the Canadian Association of Gastroenterology · 2025-02-01