Scientific Literature Search

Source record

Up-regulation of the kinase LRRK2, in enteric glia contributes to mucosal barrier impairment in Parkinson's disease via secretory autophagy.

D'Antongiovanni V, Pierucci C, Segnani C, Ippolito C, Di Salvo C, Lucarini E, Antonioli L, Fornai M, Bernardini N, Derkinderen P, Scarpignato C, Pellegrini C.

Br J Pharmacol · 2026-08-13

DOI: 10.1111/bph.70623PMID: 42593416

A bibliographic record traceable to Europe PMC.

Article details View source ↗

Open access

Parkinson's disease LRRK2 mutations dysregulate iron homeostasis and promote oxidative stress and ferroptosis in human neurons and astrocytes.

Mamais A, Batchelor RD, Chairmandurai A, Ladd TB, Shute AJ, Subrahmanian N, Maio N, Vulpe CD, LaVoie MJ.

Mol Neurodegener · 2026-07-24

DOI: 10.1186/s13024-026-00979-5PMID: 42902384

A bibliographic record traceable to Europe PMC.

Article details View source ↗

Source record

The Parkinson's disease-linked G2019S mutation of LRRK2 increases NADPH oxidase-2 activity in neutrophils for superior control of bacterial infections.

Hurley K, Kaul R, Yadav S, Rijal D, Sam L, Bhan A, Hamra RE, Ariana A, Mahdi A, Brandt W, Tomlinson JJ, Schlossmacher MG, Sad S.

Cell Mol Immunol · 2026-07-17

DOI: 10.1038/s41423-026-01451-6PMID: 42463806

A bibliographic record traceable to Europe PMC.

Article details View source ↗

Source record

Evolutionary history of LRRK2 and PRKN in leprosy and Parkinson's disease.

Cagliani R, Pozzoli U, Forni D, Mozzi A, Sironi M.

NPJ Genom Med · 2026-07-11

DOI: 10.1038/s41525-026-00596-7PMID: 42436173

A bibliographic record traceable to Europe PMC.

Article details View source ↗

Source record

Interaction of G2019S LRRK2 and metabolic syndrome in a two-hit mouse model of Parkinson's disease: LRRK2-driven systemic depletion of pyrimidine nucleosides.

Ma Y, Erb ML, Sipple KA, Offerman AV, Niu J, Madaj ZB, Fu Z, Lau KH, Moore DJ.

NPJ Parkinsons Dis · 2026-07-08

DOI: 10.1038/s41531-026-01465-xPMID: 42420315

A bibliographic record traceable to Europe PMC.

Article details View source ↗

Open access

LRRK2 Mutation Alters Dopamine D2 Receptor Localization in Induced Pluripotent Stem Cells-Derived Astrocytes From Parkinson's Disease Patients: Implications for Neuronal Damage.

Mutti V, Bono F, Tomasoni Z, Fadel D, Gnutti C, Sbrini G, Gaudenzi C, Salvi V, Bosisio D, Russo I, Bolognin S, Schwamborn JC, Missale C, Fiorentini C.

J Neurochem · 2026-07-01

DOI: 10.1111/jnc.70510PMID: 42381446

A bibliographic record traceable to Europe PMC.

Article details View source ↗

Source record

Polypharmacological Targeting of G2019S Mutant LRRK2 and JNK3 for the Discovery of a Lead Compound against Parkinson's Disease.

Kim K, Kim T, Park H, Hong S.

J Med Chem · 2026-06-22

DOI: 10.1021/acs.jmedchem.6c01439PMID: 42329175

A bibliographic record traceable to Europe PMC.

Article details View source ↗

Open access

NERINE reveals rare variant associations in gene networks across phenotypes and implicates an SNCA-PRL-LRRK2 subnetwork in Parkinson's disease.

Nazeen S, Wang X, Morrow AR, Strom R, Ethier E, Ritter D, Henderson ABH, Afroz J, Cassa CS, Stitziel NO, Gupta RM, Luk KC, Studer L, Khurana V, Sunyaev SR.

Cell Genom · 2026-06-22

DOI: 10.1016/j.xgen.2026.101284PMID: 42330948

A bibliographic record traceable to Europe PMC.

Article details View source ↗

Open access

Single-cell RNA profiling of oligodendroglial lineage cells derived from iPSCs carrying Parkinson's disease-relevant LRRK2-G2019S mutation.

Karmali N, Kessler W, Dehestani M, Sun W, Drwesh L, Volos P, Tsitkov S, Dhingra A, Thomas C, Rodriguez-Nieto S, Tietz J, Schafflick D, Fernandes N, Fitzgerald J, Fraenkel E, Gasser T, Rafiq NM, Kuhlmann T, Bansal V.

iScience · 2026-06-19

DOI: 10.1016/j.isci.2026.116368PMID: 42383004

A bibliographic record traceable to Europe PMC.

Article details View source ↗

Source record

Glial control of extracellular α-synuclein propagation in LRRK2 Parkinson's disease.

Datta I, Sahu DD.

Adv Immunol · 2026-06-16

DOI: 10.1016/bs.ai.2026.04.005PMID: 42629126

A bibliographic record traceable to Europe PMC.

Article details View source ↗

Open access

Leucine-rich repeat kinase 2 (LRRK2): balancing cellular homeostasis and Parkinson's disease (PD) pathogenesis.

Aolymat I, Abu-Hassan DW, Oleimat AK, Sameer W, Wreikat B, Iqilan T, Al-Momani H, Ali H, Tahtamouni L, Iqsairi M, Albeik M, Debas O.

Ann Med · 2026-06-03

DOI: 10.1080/07853890.2026.2677288PMID: 42233523

A bibliographic record traceable to Europe PMC.

Article details View source ↗

Open access

Regulation between LRRK2 and PP2A signaling in cellular models of Parkinson's disease.

Athanasopoulos PS, Memou A, Ho FY, Soliman A, Pots H, Papadopoulou V, von Zweydorf F, Sriraman S, Thouin AM, Vandewynckel L, Sibran W, Chartier-Harlin MC, Nichols RJ, Greggio E, Taymans JM, Gloeckner CJ, Rideout HJ, Kortholt A.

Biochem J · 2026-06-01

DOI: 10.1042/bcj20260194PMID: 42133347

A bibliographic record traceable to Europe PMC.

Article details View source ↗

Records come from scientific sources. Bibliographic counts do not represent completed translations or editorial approvals.

785 articles found

Up-regulation of the kinase LRRK2, in enteric glia contributes to mucosal barrier impairment in Parkinson's disease via secretory autophagy.

Parkinson's disease LRRK2 mutations dysregulate iron homeostasis and promote oxidative stress and ferroptosis in human neurons and astrocytes.

The Parkinson's disease-linked G2019S mutation of LRRK2 increases NADPH oxidase-2 activity in neutrophils for superior control of bacterial infections.

Evolutionary history of LRRK2 and PRKN in leprosy and Parkinson's disease.

Interaction of G2019S LRRK2 and metabolic syndrome in a two-hit mouse model of Parkinson's disease: LRRK2-driven systemic depletion of pyrimidine nucleosides.

LRRK2 Mutation Alters Dopamine D2 Receptor Localization in Induced Pluripotent Stem Cells-Derived Astrocytes From Parkinson's Disease Patients: Implications for Neuronal Damage.

Polypharmacological Targeting of G2019S Mutant LRRK2 and JNK3 for the Discovery of a Lead Compound against Parkinson's Disease.

NERINE reveals rare variant associations in gene networks across phenotypes and implicates an SNCA-PRL-LRRK2 subnetwork in Parkinson's disease.

Single-cell RNA profiling of oligodendroglial lineage cells derived from iPSCs carrying Parkinson's disease-relevant LRRK2-G2019S mutation.

Glial control of extracellular α-synuclein propagation in LRRK2 Parkinson's disease.

Leucine-rich repeat kinase 2 (LRRK2): balancing cellular homeostasis and Parkinson's disease (PD) pathogenesis.

Regulation between LRRK2 and PP2A signaling in cellular models of Parkinson's disease.

Filters