15.468 articles found

Alpha-Synuclein Gene Alterations Modulate Tyrosine Hydroxylase in Human iPSC-Derived Neurons in a Parkinson’s Disease Animal Model

Bernal-Conde L, Peña-Martínez V, Morato-Torres C, Ramos-Acevedo R, Arias-Carrión Ó, Padilla-Godínez F, Delgado-González A, Palomero-Rivero M, Collazo-Navarrete O, Soto-Rojas L, Gómez-Chavarín M, Schüle B, Guerra-Crespo M.

Life (Basel, Switzerland) · 2024-06-01

Comorbid neurotrauma increases neurodegenerative-relevant cognitive, motor, and autonomic dysfunction in patients with rapid eye movement sleep behavior disorder: a substudy of the North American Prodromal Synucleinopathy Consortium.

Elliott JE, Ligman BR, Bryant-Ekstrand MD, Keil AT, Powers K, Olivo C, Neilson LE, Postuma RB, Pelletier A, Gagnon JF, Gan-Or Z, Yu E, Liu L, St Louis EK, Forsberg LK, Fields JA, Ross OA, Huddleston DE, Bliwise DL, Avidan AY, Howell MJ, Schenck CH, McLeland J, Criswell SR, Videnovic A, During EH, Miglis MG, Shprecher DR, Lee-Iannotti JK, Boeve BF, Ju YS, Lim MM, North American Prodromal Synucleinopathy (NAPS) Consortium.

Sleep · 2024-06-01

DOI: 10.1093/sleep/zsae007PMID: 38181205

Electroencephalographic spectro-spatial covariance patterns related to phenoconversion in isolated rapid eye movement sleep behavior disorder and their longitudinal trajectories in α-synucleinopathies.

Park K, Shin JH, Byun JI, Jeong E, Kim HJ, Jung KY.

Sleep · 2024-06-01

DOI: 10.1093/sleep/zsae052PMID: 38482885

Genetic analysis and natural history of Parkinson's disease due to the LRRK2 G2019S variant.

Kmiecik MJ, Micheletti S, Coker D, Heilbron K, Shi J, Stagaman K, Filshtein Sonmez T, Fontanillas P, Shringarpure S, Wetzel M, Rowbotham HM, Cannon P, Shelton JF, Hinds DA, Tung JY, 23andMe Research Team , Holmes MV, Aslibekyan S, Norcliffe-Kaufmann L.

Brain · 2024-06-01

DOI: 10.1093/brain/awae073PMID: 38804604

Left corticospinal tract could be a biomarker to identify the dual prodromal LRRK2/GBA mutated Parkinson's disease.

Lin F, Ruan X, Zou X, Weng H, Zeng Y, Zheng J, Ye Q, Meng F, Chen X, Cai G.

CNS Neurosci Ther · 2024-06-01

DOI: 10.1111/cns.14728PMID: 38837664

[Mechanisms Underlying the Propagation of α-Synuclein Seeds Derived from the Blood of Patients with α-Synucleinopathies].

Okuzumi A, Hatano T, Hattori N.

Brain Nerve · 2024-06-01

DOI: 10.11477/mf.1416202676PMID: 38853507

ADVANCEMENT IN ALPHA-SYNUCLEIN PROTEOMICS: EXPLORING ANALYTICAL TECHNIQUES AND THEIR CLINICAL IMPLICATIONS IN PARKINSON'S DISEASE.

Palanisamy S, Subramani P, Narasimman P, Murugesan M.

Georgian Med News · 2024-06-01

PMID: 39230220

Decoding Inhibitor Egression from Wild-Type and G2019S Mutant LRRK2 Kinase: Insights into Unbinding Mechanisms for Precision Drug Design in Parkinson's Disease.

Naskar A, Roy RK, Srivastava D, Patra N.

J Phys Chem B · 2024-06-01

DOI: 10.1021/acs.jpcb.4c00335PMID: 38822803

Increased glucosylsphingosine levels and Gaucher disease in GBA1-associated Parkinson's disease.

Marano M, Zizzo C, Malaguti MC, Bacchin R, Cavallieri F, De Micco R, Spagnolo F, Bentivoglio AR, Schirinzi T, Bovenzi R, Ramat S, Erro R, Sorrentino C, Sucapane P, Pilotto A, Lupini A, Magliozzi A, Di Vico I, Carecchio M, Bonato G, Cilia R, Colucci F, Tamma F, Caputo E, Mostile G, Arabia G, Modugno N, Zibetti M, Ceravolo MG, Tambasco N, Cossu G, Valzania F, Manganotti P, Di Lazzaro V, Zappia M, Fabbrini G, Tinazzi M, Tessitore A, Duro G, Di Fonzo A.

Parkinsonism Relat Disord · 2024-06-01

DOI: 10.1016/j.parkreldis.2024.107023PMID: 38843618

Host Genetic Background Affects the Brain Weight Influenced by Obesity and Diabetes Development in Collaborative Cross Mice

Paz A, Lone IM, Midlej K, Ghnaim A, Ben-Nun N, Iraqi FA.

· 2024-05-31

DOI: 10.21203/rs.3.rs-4412575/v1

Investigation of the genetic aetiology of Lewy body diseases with and without dementia.

Wu LY, Real R, Martinez-Carrasco A, Chia R, Lawton MA, Shoai M, Bresner C, Blauwendraat C, Singleton AB, Ryten M, International Lewy Body Dementia Genomics Consortium , Scholz SW, Traynor BJ, Williams NM, Hu MTM, Ben-Shlomo Y, Grosset DG, Hardy J, Morris HR.

Brain Commun · 2024-05-31

DOI: 10.1093/braincomms/fcae190PMID: 38978726

Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein.

Mao X, Gu H, Kim D, Kimura Y, Wang N, Xu E, Kumbhar R, Ming X, Wang H, Chen C, Zhang S, Jia C, Liu Y, Bian H, Karuppagounder SS, Akkentli F, Chen Q, Jia L, Hwang H, Lee SH, Ke X, Chang M, Li A, Yang J, Rastegar C, Sriparna M, Ge P, Brahmachari S, Kim S, Zhang S, Shimoda Y, Saar M, Liu H, Kweon SH, Ying M, Workman CJ, Vignali DAA, Muller UC, Liu C, Ko HS, Dawson VL, Dawson TM.

Nat Commun · 2024-05-31

DOI: 10.1038/s41467-024-49016-3PMID: 38821932