20.927 articles found

A new strategy for the treatment of Parkinson's disease: Discovery and bio-evaluation of the first central-targeting tyrosinase inhibitor.

Qi S, Guo L, Liang J, Wang K, Liao Q, He S, Lyu W, Cheng Z, Wang J, Luo X, Yan X, Lu Z, Wang X, Wang Z, Chen X, Li Q.

Bioorg Chem · 2024-07-02

DOI: 10.1016/j.bioorg.2024.107612PMID: 38986418

Activation and Purification of ß‐Glucocerebrosidase by Exploiting its Transporter LIMP‐2 – Implications for Novel Treatment Strategies in Gaucher's and Parkinson's Disease (Adv. Sci. 25/2024)

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Advanced Science · 2024-07-01

Conservative Versus Operative Treatment of Proximal Humerus Fractures in Older Individuals.

Katthagen JC, Raschke MJ, Fischhuber K, Iking J, Marschall U, Sußiek J, Faldum A, Stolberg-Stolberg J, Köppe J.

Dtsch Arztebl Int · 2024-07-01

DOI: 10.3238/arztebl.m2024.0059PMID: 38652842

New insights into sodium phenylbutyrate as a pharmacotherapeutic option for neurological disorders.

Juarez D, Handal-Silva A, Morán-Perales JL, Torres-Cifuentes DM, Flores G, Treviño S, Moreno-Rodriguez A, Guevara J, Diaz A.

Synapse · 2024-07-01

DOI: 10.1002/syn.22301PMID: 38819491

Improved Outcomes When Home-Dose Carbidopa-Levodopa Is Continued in the Geriatric Emergency Department in Patients With Parkinson's Disease.

Yuksel JM, Ulen KR, Brenner JM, Brangman SA, Noviasky J.

Sr Care Pharm · 2024-07-01

DOI: 10.4140/tcp.n.2024.242PMID: 38937894

Levodopa modulates semantic fluency and uniqueness in non-demented patients with progressive supranuclear palsy.

Ma J, Zhang G, Zhao Z, Chan P, Ye Z.

Brain Behav · 2024-07-01

DOI: 10.1002/brb3.3606PMID: 38945805

Is appendoscope a new option for the treatment of acute appendicitis?

Feng SJ, Zhou YF, Yang JF, Shen HZ, Cui GX, Zhang XF.

World J Gastroenterol · 2024-07-01

DOI: 10.3748/wjg.v30.i28.3386PMID: 39091716

Optogenetic fMRI reveals therapeutic circuits of subthalamic nucleus deep brain stimulation.

Li Y, Lee SH, Yu C, Hsu LM, Wang TW, Do K, Kim HJ, Shih YI, Grill WM.

Brain Stimul · 2024-07-01

DOI: 10.1016/j.brs.2024.07.022PMID: 39096961

Immune responses to central nervous system directed adeno-associated virus gene therapy: Does direct CNS delivery make a difference?

Harkins AL, Ambegaokar PP, Keeler AM.

Neurotherapeutics · 2024-07-01

DOI: 10.1016/j.neurot.2024.e00435PMID: 39180957

Neurosurgical gene therapy for central nervous system diseases.

Patel RV, Nanda P, Richardson RM.

Neurotherapeutics · 2024-07-01

DOI: 10.1016/j.neurot.2024.e00434PMID: 39191071

Dose-Dependent Alterations of Lysosomal Activity and Alpha-Synuclein in Peripheral Blood Monocyte-Derived Macrophages and SH-SY5Y Neuroblastoma Cell Line by upon Inhibition of MTOR Protein Kinase - Assessment of the Prospects of Parkinson's Disease Therapy.

Bezrukova AI, Basharova KS, Baydakova GV, Zakharova EY, N Pchelina S, Usenko TS.

Biochemistry (Mosc) · 2024-07-01

DOI: 10.1134/s0006297924070113PMID: 39218026

THE EFFECTS OF HYDROCORTISONE ON SYNAPTIC PROCESSES IN PARKINSON'S DISEASE UNDERLYING THE POTENTIAL THERAPEUTIC STRATEGIES.

Poghosyan M, Stepanyan H, Avetisyan Z, Sarkissian J.

Georgian Med News · 2024-07-01

PMID: 39441309