15.814 articles found

Aggregate-prone brain regions in Parkinson's disease are rich in unique N-terminus α-synuclein conformers with high proteolysis susceptibility.

Wiseman JA, Murray HC, Faull RLMF, Dragunow M, Turner CP, Dieriks BV, Curtis MA.

NPJ Parkinsons Dis · 2024-01-02

DOI: 10.1038/s41531-023-00614-wPMID: 38167744

Constitutive Endolysosomal Perforation in Neurons allows Induction of α-Synuclein Aggregation by Internalized Pre-Formed Fibrils

Sanyal A, Scanavachi G, Somerville E, Saminathan A, Nair A, Oikonomou A, Hatzakis NS, Kirchhausen T.

· 2024-01-01

DOI: 10.1101/2023.12.30.573738

Light stress conditions affect variability in the phenotypic expression of germination in Mammillaria carnea from different origins and genetic families

Matus R, Perroni Y, Flores J, Miranda-Jácome A.

Flora. · 2024-01-01

Cerium oxide nanoparticles modulating the Parkinson's disease conditions: From the alpha synuclein structural point of view and antioxidant properties of cerium oxide nanoparticles

Yao X, Guan Y, Wang J, Wang D.

Heliyon · 2024-01-01

Aggregation and beyond: alpha-synuclein-based biomarkers in synucleinopathies.

Chopra A, Outeiro TF.

Brain · 2024-01-01

DOI: 10.1093/brain/awad260PMID: 37526295

New Pyrrolopyrimidines as LRRK2 Inhibitors for Treating Parkinson's Disease.

De SK.

Curr Med Chem · 2024-01-01

DOI: 10.2174/0929867331666230821101247PMID: 37605404

Non-Pharmacological Treatment of Autonomic Dysfunction in Parkinson's Disease and Other Synucleinopathies.

Palma JA, Thijs RD.

J Parkinsons Dis · 2024-01-01

DOI: 10.3233/jpd-230173PMID: 37694308

Graph-Based Fusion of Imaging, Genetic and Clinical Data for Degenerative Disease Diagnosis.

Guo R, Tian X, Lin H, McKenna S, Li HD, Guo F, Liu J.

IEEE/ACM Trans Comput Biol Bioinform · 2024-01-01

DOI: 10.1109/tcbb.2023.3335369PMID: 37991907

Neuronally Derived Extracellular Vesicle α-Synuclein as a Serum Biomarker for Individuals at Risk of Developing Parkinson Disease.

Yan S, Jiang C, Janzen A, Barber TR, Seger A, Sommerauer M, Davis JJ, Marek K, Hu MT, Oertel WH, Tofaris GK.

JAMA Neurol · 2024-01-01

DOI: 10.1001/jamaneurol.2023.4398PMID: 38048087

Alpha-Synuclein Pre-Formed Fibrils Injected into Prefrontal Cortex Primarily Spread to Cortical and Subcortical Structures.

Weber MA, Kerr G, Thangavel R, Conlon MM, Gumusoglu SB, Gupta K, Abdelmotilib HA, Halhouli O, Zhang Q, Geerling JC, Narayanan NS, Aldridge GM.

J Parkinsons Dis · 2024-01-01

DOI: 10.3233/jpd-230129PMID: 38189765

Beneficial effect of 5-HT1b/1d agonist on Parkinson's disease by modulating glutamate and reducing deposition of α-synuclein.

Tripathi AS, Fatima N, Tripathi P, Tripathi R, Alka, Zaki MEA, Mohapatra L, Yasir M, Maurya RK.

J Biochem Mol Toxicol · 2024-01-01

DOI: 10.1002/jbt.23627PMID: 38229316

Comprehensive analysis of clinical and biological features in Parkinson's disease associated with the LRRK2 G2019S mutation: Data from the PPMI study.

Sun X, Dou K, Xue L, Xie Y, Yang Y, Xie A.

Clin Transl Sci · 2024-01-01

DOI: 10.1111/cts.13720PMID: 38266062