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Revisiting Alpha-Synuclein Pathways to Inflammation.

Lyra P, Machado V, Rota S, Chaudhuri KR, Botelho J, Mendes JJ.

Int J Mol Sci · 2023-04-12

DOI: 10.3390/ijms24087137PMID: 37108299

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Double-Edged Effects of Venglustat on Behavior and Pathology in Mice Overexpressing α-Synuclein.

Schidlitzki A, Stanojlovic M, Fournier C, Käufer C, Feja M, Gericke B, Garzotti M, Welford RWD, Steiner MA, Angot E, Richter F.

Mov Disord · 2023-04-12

DOI: 10.1002/mds.29398PMID: 37050861

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Synaptic dysfunction and dysregulation of extracellular matrix-related genes in dopaminergic neurons derived from Parkinson’s disease sporadic patients and with GBA1 mutations

Rosh I, Tripathi U, Hussein Y, Rike WA, Manole A, Cordeiro D, Houlden H, Winkler J, Gage F, Stern S.

· 2023-04-11

DOI: 10.1101/2023.04.10.536143

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PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation

Wang S, Baumert R, Séjourné G, Sivadasan Bindu D, Dimond K, Sakers K, Vazquez L, Moore JL, Tan CX, Takano T, Rodriguez MP, Brose N, Bradley L, Lessing R, Soderling SH, La Spada AR, Eroglu C.

· 2023-04-10

DOI: 10.1101/2023.04.09.536178

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In silico investigation of the structural stability as the origin of the pathogenicity of α-synuclein protofibrils.

Yoon J, Lee M, Park Y, Lee K, Shin S.

J Biomol Struct Dyn · 2023-04-10

DOI: 10.1080/07391102.2023.2199077PMID: 37036430

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High-resolution structural information of membrane-bound α-synuclein provides insight into the MoA of the anti-Parkinson drug UCB0599.

Schwarz TC, Beier A, Ledolter K, Gossenreiter T, Höfurthner T, Hartl M, Baker TS, Taylor RJ, Konrat R.

Proc Natl Acad Sci U S A · 2023-04-07

DOI: 10.1073/pnas.2201910120PMID: 37027427

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Aberrant somatic calcium channel function in cNurr1 and LRRK2-G2019S mice.

Skiteva O, Yao N, Mantas I, Zhang X, Perlmann T, Svenningsson P, Chergui K.

NPJ Parkinsons Dis · 2023-04-07

DOI: 10.1038/s41531-023-00500-5PMID: 37029193

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Sleep and circadian rhythms in α-synucleinopathies-Perspectives for disease modification.

Kunz D, Oster H, Rawashdeh O, Neumann WJ, Münte T, Berg D.

Acta Physiol (Oxf) · 2023-04-07

DOI: 10.1111/apha.13966PMID: 36951649

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MALAT1 Mediates α-Synuclein Expression through miR-23b-3p to Induce Autophagic Impairment and the Inflammatory Response in Microglia to Promote Apoptosis in Dopaminergic Neuronal Cells.

Geng X, Zou Y, Li S, Qi R, Yu H, Li J.

Mediators Inflamm · 2023-04-06

DOI: 10.1155/2023/4477492PMID: 37064502

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Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage.

Rosado-Ramos R, Poças GM, Marques D, Foito A, M Sevillano D, Lopes-da-Silva M, Gonçalves LG, Menezes R, Ottens M, Stewart D, Ibáñez de Opakua A, Zweckstetter M, Seabra MC, Mendes CS, Outeiro TF, Domingos PM, Santos CN.

Nat Commun · 2023-04-06

DOI: 10.1038/s41467-023-37561-2PMID: 37024503

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Exploring the genetic and genomic connection underlying neurodegeneration with brain iron accumulation and the risk for Parkinson's disease.

Alvarez Jerez P, Alcantud JL, de Los Reyes-Ramírez L, Moore A, Ruz C, Vives Montero F, Rodriguez-Losada N, Saini P, Gan-Or Z, Alvarado CX, Makarious MB, Billingsley KJ, Blauwendraat C, Noyce AJ, Singleton AB, Duran R, Bandres-Ciga S.

NPJ Parkinsons Dis · 2023-04-06

DOI: 10.1038/s41531-023-00496-yPMID: 37024536

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LRRK2 and Parkinson's disease: from genetics to targeted therapy.

Sosero YL, Gan-Or Z.

Ann Clin Transl Neurol · 2023-04-06

DOI: 10.1002/acn3.51776PMID: 37021623

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Records come from scientific sources. Bibliographic counts do not represent completed translations or editorial approvals.

15.843 articles found

Revisiting Alpha-Synuclein Pathways to Inflammation.

Double-Edged Effects of Venglustat on Behavior and Pathology in Mice Overexpressing α-Synuclein.

Synaptic dysfunction and dysregulation of extracellular matrix-related genes in dopaminergic neurons derived from Parkinson’s disease sporadic patients and with <i>GBA1</i> mutations

PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation

In silico investigation of the structural stability as the origin of the pathogenicity of <i>α</i>-synuclein protofibrils.

High-resolution structural information of membrane-bound α-synuclein provides insight into the MoA of the anti-Parkinson drug UCB0599.

Aberrant somatic calcium channel function in cNurr1 and LRRK2-G2019S mice.

Sleep and circadian rhythms in α-synucleinopathies-Perspectives for disease modification.

MALAT1 Mediates <i>α</i>-Synuclein Expression through miR-23b-3p to Induce Autophagic Impairment and the Inflammatory Response in Microglia to Promote Apoptosis in Dopaminergic Neuronal Cells.

Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage.

Exploring the genetic and genomic connection underlying neurodegeneration with brain iron accumulation and the risk for Parkinson's disease.

LRRK2 and Parkinson's disease: from genetics to targeted therapy.

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