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Discovery of Potent, Selective, CNS-Penetrant Macrocyclic LRRK2 Inhibitors for the Treatment of Parkinson's Disease.

Yu EC, Zhou H, Yan X, Logan KM, Li D, Gulati A, Poremba KE, Ardolino MJ, Su J, Xiao D, Palte RL, McMinn SE, Nogle LM, Adpressa DA, Burgess SA, Xiong T, Otte KM, Chobanian HR, Bass A, Lee S, Pearson K, Messina E, Parisi M, Barnum J, Sobol Z, Ciaccio PJ, DiMauro EF, Fell MJ, Fuller PH.

J Med Chem · 2026-03-29

DOI: 10.1021/acs.jmedchem.6c00238PMID: 41906303

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
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Bridging Genetics and Precision Medicine in Parkinson’s Disease through GP2

Atterling Brolin K, Lange LM, Navarro-Jones E, Jasaityte S, Ye Beh Y, Fang Z, Iwaki H, Jones L, Klein C, Kleinz T, Leonard HL, Mata IF, Noyce AJ, Okubadejo N, Saffie Awad P, Screven L, Tan AH, Toffoli M, Vitale D, Singleton A, Blauwendraat C, Nalls M, Morris HR, the Global Parkinson’s Genetics Program (GP2).

· 2026-03-28

DOI: 10.64898/2026.03.26.26349418

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.

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