Scientific Literature Search

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The function of Golgi apparatus in LRRK2-associated Parkinson's disease.

Wei Y, Awan MUN, Bai L, Bai J.

Front Mol Neurosci · 2023-02-21

DOI: 10.3389/fnmol.2023.1097633PMID: 36896008

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Spontaneous nucleation and fast aggregate-dependent proliferation of α-synuclein aggregates within liquid condensates at neutral pH.

Dada ST, Hardenberg MC, Toprakcioglu Z, Mrugalla LK, Cali MP, McKeon MO, Klimont E, Michaels TCT, Knowles TPJ, Vendruscolo M.

Proc Natl Acad Sci U S A · 2023-02-21

DOI: 10.1073/pnas.2208792120PMID: 36802433

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Drug repurposing screens identify compounds that inhibit α-synuclein oligomers' membrane disruption and block antibody interactions.

Somavarapu AK, Kleijwegt G, Nagaraj M, Alam P, Nielsen J, Otzen DE.

Chem Sci · 2023-02-21

DOI: 10.1039/d2sc05534aPMID: 36937574

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Nicotine-Mediated Recruitment of GABAergic Neurons to a Dopaminergic Phenotype Attenuates Motor Deficits in an Alpha-Synuclein Parkinson's Model.

Lai JI, Porcu A, Romoli B, Keisler M, Manfredsson FP, Powell SB, Dulcis D.

Int J Mol Sci · 2023-02-20

DOI: 10.3390/ijms24044204PMID: 36835612

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Structural and dynamic insights into α-synuclein dimer conformations.

Zamel J, Chen J, Zaer S, Harris PD, Drori P, Lebendiker M, Kalisman N, Dokholyan NV, Lerner E.

Structure · 2023-02-20

DOI: 10.1016/j.str.2023.01.011PMID: 36809765

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Open access

Genome-wide screen reveals Rab12 GTPase as a critical activator of pathogenic LRRK2 kinase

Dhekne HS, Tonelli F, Yeshaw WM, Chiang CY, Limouse C, Jaimon E, Purlyte E, Alessi DR, Pfeffer SR.

· 2023-02-18

DOI: 10.1101/2023.02.17.529028

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LRRK2 Inhibition by BIIB122 in Healthy Participants and Patients with Parkinson's Disease.

Jennings D, Huntwork-Rodriguez S, Vissers MFJM, Daryani VM, Diaz D, Goo MS, Chen JJ, Maciuca R, Fraser K, Mabrouk OS, van de Wetering de Rooij J, Heuberger JAAC, Groeneveld GJ, Borin MT, Cruz-Herranz A, Graham D, Scearce-Levie K, De Vicente J, Henry AG, Chin P, Ho C, Troyer MD.

Mov Disord · 2023-02-18

DOI: 10.1002/mds.29297PMID: 36807624

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LRRK2 Quantification in Cerebrospinal Fluid of Patients with Parkinson's Disease and Atypical Parkinsonian Syndromes.

Mancini A, Stoops E, Demeyer L, Bellomo G, Paolini Paoletti F, Gaetani L, Di Filippo M, Parnetti L.

Mov Disord · 2023-02-18

DOI: 10.1002/mds.29336PMID: 36808643

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Open access

Genetic forms of primary progressive aphasia within the GENetic Frontotemporal dementia Initiative (GENFI) cohort: comparison with sporadic primary progressive aphasia.

Samra K, MacDougall AM, Bouzigues A, Bocchetta M, Cash DM, Greaves CV, Convery RS, Hardy C, van Swieten JC, Seelaar H, Jiskoot LC, Moreno F, Sanchez-Valle R, Laforce R, Graff C, Masellis M, Tartaglia MC, Rowe JB, Borroni B, Finger E, Synofzik M, Galimberti D, Vandenberghe R, de Mendonça A, Butler CR, Gerhard A, Ducharme S, Le Ber I, Santana I, Pasquier F, Levin J, Otto M, Sorbi S, Warren JD, Rohrer JD, Russell LL, GENetic Frontotemporal dementia Initiative (GENFI) .

Brain Commun · 2023-02-17

DOI: 10.1093/braincomms/fcad036PMID: 36938528

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The alteration of intestinal mucosal α-synuclein expression and mucosal microbiota in Parkinson's disease.

Shi J, Wang Y, Chen D, Xu X, Li W, Li K, He J, Su W, Luo Q.

Appl Microbiol Biotechnol · 2023-02-16

DOI: 10.1007/s00253-023-12410-wPMID: 36795141

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Amphiphilic Polyamine α-Synuclein Aggregation Inhibitors from the Sponge <i>Aaptos lobata</i>.

Voser TM, Hayton JB, Prebble DW, Jin J, Grant G, Ekins MG, Carroll AR.

J Nat Prod · 2023-02-16

DOI: 10.1021/acs.jnatprod.2c01125PMID: 36795859

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Free-Water Imaging of the Substantia Nigra in GBA Pathogenic Variant Carriers.

Zhang D, Shi Y, Yao J, Zhou L, Wei H, Liu J, Tong Q, Ma L, He H, Wu T.

Mov Disord · 2023-02-16

DOI: 10.1002/mds.29356PMID: 36797645

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Records come from scientific sources. Bibliographic counts do not represent completed translations or editorial approvals.

15.843 articles found

The function of Golgi apparatus in LRRK2-associated Parkinson's disease.

Spontaneous nucleation and fast aggregate-dependent proliferation of α-synuclein aggregates within liquid condensates at neutral pH.

Drug repurposing screens identify compounds that inhibit α-synuclein oligomers' membrane disruption and block antibody interactions.

Nicotine-Mediated Recruitment of GABAergic Neurons to a Dopaminergic Phenotype Attenuates Motor Deficits in an Alpha-Synuclein Parkinson's Model.

Structural and dynamic insights into α-synuclein dimer conformations.

Genome-wide screen reveals Rab12 GTPase as a critical activator of pathogenic LRRK2 kinase

LRRK2 Inhibition by BIIB122 in Healthy Participants and Patients with Parkinson's Disease.

LRRK2 Quantification in Cerebrospinal Fluid of Patients with Parkinson's Disease and Atypical Parkinsonian Syndromes.

Genetic forms of primary progressive aphasia within the GENetic Frontotemporal dementia Initiative (GENFI) cohort: comparison with sporadic primary progressive aphasia.

The alteration of intestinal mucosal α-synuclein expression and mucosal microbiota in Parkinson's disease.

Amphiphilic Polyamine α-Synuclein Aggregation Inhibitors from the Sponge <i>Aaptos lobata</i>.

Free-Water Imaging of the Substantia Nigra in GBA Pathogenic Variant Carriers.

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