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Discovery of Potent, Selective, CNS-Penetrant Macrocyclic LRRK2 Inhibitors for the Treatment of Parkinson's Disease.

Yu EC, Zhou H, Yan X, Logan KM, Li D, Gulati A, Poremba KE, Ardolino MJ, Su J, Xiao D, Palte RL, McMinn SE, Nogle LM, Adpressa DA, Burgess SA, Xiong T, Otte KM, Chobanian HR, Bass A, Lee S, Pearson K, Messina E, Parisi M, Barnum J, Sobol Z, Ciaccio PJ, DiMauro EF, Fell MJ, Fuller PH.

J Med Chem · 2026-03-29

DOI: 10.1021/acs.jmedchem.6c00238PMID: 41906303

A bibliographic record traceable to Europe PMC.

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The genetic spectrum of LRRK2 variants in Parkinson's disease: findings from a large Chinese cohort.

Wan J, Pan H, Chang D, Zhao Y, Xu Q, Yao L, Sun Q, Zhang X, He R, Wang C, Zhang H, Lei L, Wang Y, Li M, Wu H, Ma J, Wu Y, Xu Y, Xiong N, Wang T, Wang X, Chen L, Xu Y, Cao H, Zhang K, Liu W, Zhang Y, Mao C, Wang Q, Xue Z, Zhang Z, Cheng O, Huang W, Zhao G, Cui G, Chen T, Wang P, Di W, Liu H, Zheng H, Chen C, Guo H, Xia K, Zhang Z, Yuan K, Li J, Wang J, Guo J, Shen L, Jiang H, Liu C, Liu J, Chan P, Liu Z, Tang B, Parkinson’s Disease & Movement Disorders Multicenter Database and Collaborative Network in China (PD-MDCNC), China Essential Tremor Alliance (CETA).

NPJ Parkinsons Dis · 2026-03-28

DOI: 10.1038/s41531-026-01315-wPMID: 41904258

A bibliographic record traceable to Europe PMC.

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Erratum for the Research Article "Parkinson's VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B" by P. Pal <i>et al</i>.

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Sci Adv · 2026-03-27

DOI: 10.1126/sciadv.aeg9560PMID: 41894517

A bibliographic record traceable to Europe PMC.

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LRRK2-targeting antisense oligonucleotide in Parkinson's disease: a phase 1 randomized controlled trial.

Mabrouk OS, Tichler B, Arnold HM, Thoma EC, Alexanian SM, Chen J, Liu TY, Hirschhorn B, Llorens Arenas R, Annand JW, Kapadnis U, Shomo AA, Glajch KE, Ferber K, Moroishi Y, Czerkowicz J, Inra J, Postuma RB, Gurevich T, Mir P, Morris HR, Aldred J, Brodsky MA, Ellenbogen A, Larson D, Tolleson CM, Siderowf A, Tzoulis C, Balaguer E, Marti MJ, Zhao HT, Kordasiewicz HB, Lane R, Hirst WD, Fradette S, Graham DL.

Nat Med · 2026-03-24

DOI: 10.1038/s41591-026-04262-4PMID: 41876647

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.

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Mechanistic of LRRK2-Mediated Pyroptosis Via the NLRP3/Caspase-1/GSDMD Pathway in Parkinson's Disease Progression.

Li J, Zheng Z, Zhang X, Shen L, Xue C, Lu L, Xu X, Li F, Lu G.

Inflammation · 2026-03-14

DOI: 10.1007/s10753-026-02475-wPMID: 41831074

A bibliographic record traceable to Europe PMC.

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LRRK2 kinase mediates increased GCase activity in microglia in response to IFNγ-induced proinflammatory stimulation.

MacDougall EJ, Chen CX, Deneault E, You Z, Kalaydjian D, Abdian N, Durcan TM, Senkevich K, Gan-Or Z, Fon EA.

NPJ Parkinsons Dis · 2026-03-06

DOI: 10.1038/s41531-026-01310-1PMID: 41786767

A bibliographic record traceable to Europe PMC.

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Advancing Development of LRRK2-Targeted Therapeutics for Parkinson's Disease: Conference Proceedings and Roadmap for Research.

Predmore Z, Donofry SD.

Rand Health Q · 2026-03-05

DOI: 10.7249/rhq-13-02-02PMID: 41821671

A bibliographic record traceable to Europe PMC.

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The Age at Onset of LRRK2 p.Gly2019Ser Parkinson's Disease Across Ancestries and Countries of Origin.

Lüth T, Laabs BH, Sendel S, König IR, Caliebe A, Noyce AJ, Screven LA, Bardien S, Farrer M, Hentati F, Amouri R, Klein C, Sassi SB, Trinh J, Global Parkinson's Genetics Program (GP2).

Ann Neurol · 2026-02-24

DOI: 10.1002/ana.78181PMID: 41735653

A bibliographic record traceable to Europe PMC.

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APOE, Aβ42, and tau differentially impact cognitive decline in Sporadic, GBA1 and LRRK2 Parkinson's disease.

Botta R, Locascio JJ, Ye R, Goodheart AE, Gomperts SN.

NPJ Parkinsons Dis · 2026-02-23

DOI: 10.1038/s41531-026-01290-2PMID: 41730900

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.

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CSF LRRK2: A biomarker for slower autonomic dysfunction progression in sporadic Parkinson's disease.

Chen S, Shen Y, Shao J, Li R, Hao X, Yang H, Ma K, Zhang J.

Auton Neurosci · 2026-02-18

DOI: 10.1016/j.autneu.2026.103399PMID: 41762849

A bibliographic record traceable to Europe PMC.

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Membrane Dysfunction as a Central Mechanism in LRRK2-Associated Parkinson's Disease: Comparative Analysis of G2019S and I1371V Variants.

Singh K, Banerjee R, Potdar C, Shaw A, Rakshith R, Kamble N, Holla V, Yadav R, Pal PK, Datta I.

Cells · 2026-02-13

DOI: 10.3390/cells15040342PMID: 41744785

A bibliographic record traceable to Europe PMC.

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Open access

LRRK2<sup>R1627P</sup> mutation amplifies environmental risk factors induced chronic inflammation and α-synuclein aggregation in the gut of rats.

Pang S, Lu J, Wang Y, Ying C, Zhao C, Yue Z, Yang Q, Chan P.

NPJ Parkinsons Dis · 2026-02-07

DOI: 10.1038/s41531-026-01281-3PMID: 41654526

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.

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Records come from scientific sources. Bibliographic counts do not represent completed translations or editorial approvals.

1.203 articles found

Discovery of Potent, Selective, CNS-Penetrant Macrocyclic LRRK2 Inhibitors for the Treatment of Parkinson's Disease.

The genetic spectrum of LRRK2 variants in Parkinson's disease: findings from a large Chinese cohort.

Erratum for the Research Article "Parkinson's VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B" by P. Pal <i>et al</i>.

LRRK2-targeting antisense oligonucleotide in Parkinson's disease: a phase 1 randomized controlled trial.

Mechanistic of LRRK2-Mediated Pyroptosis Via the NLRP3/Caspase-1/GSDMD Pathway in Parkinson's Disease Progression.

LRRK2 kinase mediates increased GCase activity in microglia in response to IFNγ-induced proinflammatory stimulation.

Advancing Development of LRRK2-Targeted Therapeutics for Parkinson's Disease: Conference Proceedings and Roadmap for Research.

The Age at Onset of LRRK2 p.Gly2019Ser Parkinson's Disease Across Ancestries and Countries of Origin.

APOE, Aβ42, and tau differentially impact cognitive decline in Sporadic, GBA1 and LRRK2 Parkinson's disease.

CSF LRRK2: A biomarker for slower autonomic dysfunction progression in sporadic Parkinson's disease.

Membrane Dysfunction as a Central Mechanism in LRRK2-Associated Parkinson's Disease: Comparative Analysis of G2019S and I1371V Variants.

LRRK2<sup>R1627P</sup> mutation amplifies environmental risk factors induced chronic inflammation and α-synuclein aggregation in the gut of rats.

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