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Peripheral B cell immune dysregulation genetically contributes to stage-dependent neuroinflammation and identifies priority therapeutic targets in Parkinson's disease: a computational integration of Mendelian randomization and single-cell transcriptomics.

Zhang L, Fu C, Gao T, Yang K, Ouyang G, Chen W.

Front Med (Lausanne) · 2026-06-09

DOI: 10.3389/fmed.2026.1853077PMID: 42344507

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
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Impact of genetic variants in the longevity gene PPARGC1A and cerebrospinal fluid PPARγ levels on clinical trajectories in Parkinson's disease: Potential biomarkers for neurodegeneration and ageing.

Fandrich M, Schulte C, Jakobi M, Roeben B, Wurster I, Lerche S, Zimmermann S, Deuschle C, Schneiderhan-Marra N, Joos TO, Gasser T, Brockmann K, Zimmermann M.

Parkinsonism Relat Disord · 2026-06-09

DOI: 10.1016/j.parkreldis.2026.108380PMID: 42288107

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
Open access

Lysine acetyltransferase 8-mediated histone acetylation, regulated by GBA1, is associated with lysosomal function related to α-Synuclein pathology.

Cao Y, Zhang Z, Gu X, Lu H, Wu J, Zhang C, Huang X, Qin H, Liu F, Liu Z, Tang B, Lu X, Ren H, Sun H, Wang R, Wang G.

Cell Death Dis · 2026-06-08

DOI: 10.1038/s41419-026-08928-2PMID: 42252285

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
Open access

Locus coeruleus α-synuclein overexpression induces prodromal Parkinsonian features in mice.

Razquin J, De Las Heras-García L, Vaquero-Rodríguez A, Fernández-Roqueñí S, González-Aseguinolaza G, Soria-Gómez E, Baufreton J, Bengoetxea H, Abecia L, Ortega JE, Ortuzar N, Miguélez C.

NPJ Parkinsons Dis · 2026-06-08

DOI: 10.1038/s41531-026-01420-wPMID: 42259817

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
Open access

Synucleinopathy-like clinical features and biologically defined synuclein seeding in PSP-Parkinsonism: an imperfect match.

Painous C, Martínez A, Camara A, Fernandez M, Marti MJ, Muñoz E, Sánchez-Gómez A, Pérez-Soriano A, Garrido A, Brenlla C, Valldeoriola F, Tolosa E, Caballol N, Jaumà S, Pont-Sunyer C, Delgado T, Lladó A, Pérez-Montesino J, de Mena L, Naranjo L, Ruiz-García R, Molina-Porcel L, Aldecoa I, Barcelona PSP Registry Consortium, Santamaria J, Compta Y.

NPJ Parkinsons Dis · 2026-06-08

DOI: 10.1038/s41531-026-01387-8PMID: 42259819

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.

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