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A human <i>GBA-L444P</i> transgene drives early and persistent dopamine neurotransmission deficits and alpha-synuclein pathology in a mouse model of early Parkinson’s disease

Connor-Robson N, Diviney T, Alegre-Abarrategui J, Roberts B, Brimblecombe KR, Bengoa-Vergniory N, Waters H, Cioroch M, Davies B, Bila KO, van der Lienden MJC, Aerts JMFG, Cragg S, Wade-Martins R.

· 2026-05-27

DOI: 10.64898/2026.05.25.727583

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
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Genetically Encoded Constitutive Upregulation of β2 Subunit-Containing Neuronal Nicotinic Acetylcholine Receptors Is Neuroprotective in Female Parkinsonian Mice.

Pandey G, Garcia RC, Das D, Mohan AR, Rodriguez C, Pollock D, Karthik N, Nalluri S, Nguyen T, Polo C, Zarate SM, Rimer M, Srinivasan R.

J Neurosci · 2026-05-27

DOI: 10.1523/jneurosci.1368-25.2026PMID: 42049511

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
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The PET tracer [&lt;sup&gt;11&lt;/sup&gt;C]MODAG-005 targets alpha-synuclein aggregates in the brain.

Saw RS, Haas S, Schmidt F, Ryazanov S, Leonov A, Bleher D, Grotegerd AK, Kuebler L, Roeben B, Schmidt F, Reimold M, Bonanno F, Ruf VC, Dahl B, Sandiego CM, Henry KE, Papadopoulos I, Schaller M, Kahle PJ, Levin J, Gasser T, Brockmann K, Reischl G, la Fougère C, Pichler BJ, Maurer A, Griesinger C, Giese A, Herfert K.

Sci Transl Med · 2026-05-27

DOI: 10.1126/scitranslmed.aec0813PMID: 42202047

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
Open access

Inter-assay and Inter-site Performance of Alpha-Synuclein Seed Amplification Assays in Synucleinopathies: A Multicenter 2 × 2 Protocol Comparison.

Plaza-Clar R, Weber M, Kadam V, Deuschle C, Ma Y, Farris CM, Concha-Marambio L, Mengel D, Rossi M, Mammana A, Parchi P, Synofzik M, Brockmann K, Gasser T.

Neurol Ther · 2026-05-27

DOI: 10.1007/s40120-026-00965-5PMID: 42201636

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.

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