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Overexpression of α-synuclein inhibits mitochondrial Ca<sup>2+</sup> trafficking between the endoplasmic reticulum and mitochondria through MAMs by altering the GRP75-IP3R interaction.

Erustes AG, D'Eletto M, Guarache GC, Ureshino RP, Bincoletto C, da Silva Pereira GJ, Piacentini M, Smaili SS.

J Neurosci Res · 2021-09-12

DOI: 10.1002/jnr.24952PMID: 34510532

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
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The AKT modulator A-443654 reduces α-synuclein expression and normalizes ER stress and autophagy.

Gandelman M, Dansithong W, Kales SC, Paul S, Maag G, Aoyama E, Zakharov A, Rai G, Dexheimer T, Whitehill BM, Sun H, Jadhav A, Simeonov A, Henderson MJ, Huynh DP, Pulst SM, Scoles DR.

J Biol Chem · 2021-09-11

DOI: 10.1016/j.jbc.2021.101191PMID: 34520759

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
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A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy.

Cosden M, Jinn S, Yao L, Gretzula CA, Kandebo M, Toolan D, Hatcher NG, Ma L, Lemaire W, Adam GC, Burlein C, Minnick C, Flick R, Watt ML, Mulhearn J, Fraley M, Drolet RE, Marcus JN, Smith SM.

Neurobiol Dis · 2021-09-09

DOI: 10.1016/j.nbd.2021.105507PMID: 34509608

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.

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