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LRRK2 and Parkinson disease.

Dächsel JC, Farrer MJ.

Arch Neurol · 2010-05-01

DOI: 10.1001/archneurol.2010.79PMID: 20457952

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[Genetic screening for the LRRK2, G2019S and R1441 codon mutations in Parkinson's disease patients from Extremadura, Spain].

Morán JM, Castellanos-Pinedo F, Casado-Naranjo I, Durán-Herrera C, Ramírez-Moreno JM, Gómez M, Zurdo-Hernández JM, Fuentes E, Ortiz-Ortiz MA, Moreno AD, González-Polo RA, Niso-Santano M, Bravo-Sanpedro JM, Pérez-Tur J, Ruiz-Mesa LM, Fuentes JM.

Rev Neurol · 2010-05-01

DOI: 10.33588/rn.5010.2009580PMID: 20473834

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Open access

Deletion of the WD40 domain of LRRK2 in Zebrafish causes Parkinsonism-like loss of neurons and locomotive defect.

Sheng D, Qu D, Kwok KH, Ng SS, Lim AY, Aw SS, Lee CW, Sung WK, Tan EK, Lufkin T, Jesuthasan S, Sinnakaruppan M, Liu J.

PLoS Genet · 2010-04-22

DOI: 10.1371/journal.pgen.1000914PMID: 20421934

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LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease.

Yao C, El Khoury R, Wang W, Byrd TA, Pehek EA, Thacker C, Zhu X, Smith MA, Wilson-Delfosse AL, Chen SG.

Neurobiol Dis · 2010-04-09

DOI: 10.1016/j.nbd.2010.04.002PMID: 20382224

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Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2.

Gloeckner CJ, Boldt K, von Zweydorf F, Helm S, Wiesent L, Sarioglu H, Ueffing M.

J Proteome Res · 2010-04-01

DOI: 10.1021/pr9008578PMID: 20108944

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Biochemical and molecular features of LRRK2 and its pathophysiological roles in Parkinson's disease.

Seol W.

BMB Rep · 2010-04-01

DOI: 10.5483/bmbrep.2010.43.4.233PMID: 20423607

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Involvement of the cerebral cortex in Parkinson disease linked with G2019S LRRK2 mutation without cognitive impairment.

Gomez A, Ferrer I.

Acta Neuropathol · 2010-03-16

DOI: 10.1007/s00401-010-0669-yPMID: 20232069

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Parkinson's disease-related LRRK2 G2019S mutation results from independent mutational events in humans.

Lesage S, Patin E, Condroyer C, Leutenegger AL, Lohmann E, Giladi N, Bar-Shira A, Belarbi S, Hecham N, Pollak P, Ouvrard-Hernandez AM, Bardien S, Carr J, Benhassine T, Tomiyama H, Pirkevi C, Hamadouche T, Cazeneuve C, Basak AN, Hattori N, Dürr A, Tazir M, Orr-Urtreger A, Quintana-Murci L, Brice A, French Parkinson's Disease Genetics Study Group.

Hum Mol Genet · 2010-03-02

DOI: 10.1093/hmg/ddq081PMID: 20197411

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Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, alpha-synuclein, and tau.

Taymans JM, Cookson MR.

Bioessays · 2010-03-01

DOI: 10.1002/bies.200900163PMID: 20127702

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Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's disease.

Alcalay RN, Mejia-Santana H, Tang MX, Rakitin B, Rosado L, Ross B, Verbitsky M, Kisselev S, Louis ED, Comella CL, Colcher A, Jennings D, Nance MA, Bressman S, Scott WK, Tanner C, Mickel SF, Andrews HF, Waters CH, Fahn S, Cote LJ, Frucht SJ, Ford B, Rezak M, Novak K, Friedman JH, Pfeiffer R, Marsh L, Hiner B, Siderowf A, Ottman R, Clark LN, Marder KS, Caccappolo E.

J Clin Exp Neuropsychol · 2010-02-24

DOI: 10.1080/13803390903521018PMID: 20182943

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Heterodimerization of Lrrk1-Lrrk2: Implications for LRRK2-associated Parkinson disease.

Dachsel JC, Nishioka K, Vilariño-Güell C, Lincoln SJ, Soto-Ortolaza AI, Kachergus J, Hinkle KM, Heckman MG, Jasinska-Myga B, Taylor JP, Dickson DW, Gibson RA, Hentati F, Ross OA, Farrer MJ.

Mech Ageing Dev · 2010-02-06

DOI: 10.1016/j.mad.2010.01.009PMID: 20144646

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Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S.

Li X, Patel JC, Wang J, Avshalumov MV, Nicholson C, Buxbaum JD, Elder GA, Rice ME, Yue Z.

J Neurosci · 2010-02-01

DOI: 10.1523/jneurosci.5604-09.2010PMID: 20130188

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Records come from scientific sources. Bibliographic counts do not represent completed translations or editorial approvals.

1.241 articles found

LRRK2 and Parkinson disease.

[Genetic screening for the LRRK2, G2019S and R1441 codon mutations in Parkinson's disease patients from Extremadura, Spain].

Deletion of the WD40 domain of LRRK2 in Zebrafish causes Parkinsonism-like loss of neurons and locomotive defect.

LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease.

Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2.

Biochemical and molecular features of LRRK2 and its pathophysiological roles in Parkinson's disease.

Involvement of the cerebral cortex in Parkinson disease linked with G2019S LRRK2 mutation without cognitive impairment.

Parkinson's disease-related LRRK2 G2019S mutation results from independent mutational events in humans.

Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, alpha-synuclein, and tau.

Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's disease.

Heterodimerization of Lrrk1-Lrrk2: Implications for LRRK2-associated Parkinson disease.

Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S.

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