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“Parkinson LRRK2” Clear search

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Restoration of Lysosomal Hydrolase Activities by LRRK2 Inhibition in GBA1- and LRRK2-Associated Parkinson's Disease Patient-Derived Cells.

Usenko TS, Basharova KS, Bezrukova AI, Grigor'eva EV, Pavlova SV, Baydakova GV, Nikolaev MA, Gaponenko IN, Khegay OV, Miliukhina IV, Zakharova EY, Pchelina SN.

J Neurochem · 2025-09-01

DOI: 10.1111/jnc.70214PMID: 40899651

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
Open access

Lrrk2 G2019S mutation incites increased cell-intrinsic neutrophil effector functions and intestinal inflammation in a model of infectious colitis.

Pei J, Oliveira NL, Recinto SJ, Kazanova A, Queiroz-Junior CM, Li Z, Couto K, Westfall S, Fahmy AM, Tiefensee-Ribeiro C, King IL, Milnerwood AJ, Desjardins M, Thanabalasuriar A, Stratton JA, Gruenheid S.

NPJ Parkinsons Dis · 2025-08-29

DOI: 10.1038/s41531-025-01077-xPMID: 40883285

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
Open access

LRRK2-mutant microglia and neuromelanin synergize to drive dopaminergic neurodegeneration in an iPSC-based Parkinson's disease model.

Blasco-Agell L, Pons-Espinal M, Testa V, Roch G, Montero-Muñoz J, Fernandez-Carasa I, Baruffi V, Gonzalez-Sepulveda M, Richaud-Patin Y, Jimenez S, Cuadros T, Cladera-Sastre JM, Compte J, Manglano-Artuñedo Z, Ventura S, Juan M, Tolosa E, Raya A, Vila M, Consiglio A.

Commun Biol · 2025-08-12

DOI: 10.1038/s42003-025-08544-4PMID: 40796643

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
Open access

LRRK2 kinase activity regulates Parkinson's disease-relevant lipids at the lysosome.

Maloney MT, Wang X, Ghosh R, Andrews SV, Maciuca R, Masoud ST, Agam M, Caprioli RM, Astarita G, Bondar VV, Chen J, Chiu CL, Davis SS, Ho AC, Nguyen HN, Propson NE, Reyzer ML, Davis OB, Deen MC, Zhu S, Di Paolo G, Vocadlo DJ, Estrada AA, de Vicente J, Lewcock JW, Arguello A, Suh JH, Huntwork-Rodriguez S, Henry AG.

Mol Neurodegener · 2025-08-06

DOI: 10.1186/s13024-025-00880-7PMID: 40770658

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.

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