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Taurochenodeoxycholic acid activates autophagy and suppresses inflammatory responses in microglia of MPTP-induced Parkinson's disease mice via AMPK/mTOR, AKT/NFκB and Pink1/Parkin signaling pathways mediated by Takeda G protein-coupled receptor 5.

Ni C, Wang L, Bai Y, Huang F, Shi H, Wu H, Wu X, Huang J.

Free Radic Biol Med · 2025-05-03

DOI: 10.1016/j.freeradbiomed.2025.04.053PMID: 40324640

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
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Single-cell multiomics identifies both shared and unique features of immune dysfunction in Parkinson’s disease and inflammatory bowel disease colon, plasma and stool

Bolen ML, Buendia M, Shi J, Staley H, Kachergus JM, Efron PA, Park G, Nagpal R, Alvarez SD, Xue Q, McFarland NR, Zimmermann EM, Forsmark CE, Menees KB, Salas A, Thompson EA, Tansey MG.

· 2025-05-02

DOI: 10.1101/2025.04.29.651228

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
Open access

Randomized, double-blind, placebo-controlled pilot study of metformin as an adjunctive therapy in Parkinson's disease.

AlRasheed HA, Bahaa MM, Elmasry TA, Elberri EI, Kotkata FA, El Sabaa RM, Elmorsi YM, Kamel MM, Negm WA, Hamouda AO, Aldossary KM, Salahuddin MM, Yasser M, Eldesouqui M, Hamouda MA, Eltantawy N, Elawady ME, Abdallah MS.

Front Pharmacol · 2025-05-02

DOI: 10.3389/fphar.2025.1497261PMID: 40385486

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.

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