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Long-term oral glucocerebrosidase activator reduces soluble α-synuclein oligomer accumulation in Parkinsonian LRRK2 mutant mouse brain.

Choi ZY, Liu H, Chang EE, Pang SY, Luo IL, Ruan Y, Wang Q, Malki Y, Zhang SX, Weng KY, Lau BW, Ng RC, Zhang Z, Ho SL, Ho PW.

NPJ Parkinsons Dis · 2025-12-12

DOI: 10.1038/s41531-025-01205-7PMID: 41388030

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
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Investigating the shared genetic architecture between post-traumatic stress disorder and neurodegenerative diseases: a large-scale genomewide cross-trait analysis.

Shi Y, Zhao T, Peng L, Wang P, Huang X, Xu F, Tan Y, Peng S, Xiong T, Bai Y, Liu X, Wei C, Zhang W, Ding H.

Int J Surg · 2025-12-11

DOI: 10.1097/js9.0000000000004347PMID: 41376376

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
Open access

Lack of functional STING modulates immunity but does not protect dopaminergic neurons in the alpha-synuclein pre-formed fibrils Parkinson's disease mouse model.

Klæstrup IH, Reinert LS, Ferreira SA, Lauritsen J, Toft GU, Gram H, Jensen PH, Paludan SR, Romero-Ramos M.

NPJ Parkinsons Dis · 2025-12-11

DOI: 10.1038/s41531-025-01228-0PMID: 41381624

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
Open access

Seed amplification of MSA alpha-synuclein aggregates preserves the biological and structural properties of brain-derived aggregates.

Wang F, Banerjee V, Barria C, Ramirez S, Allison T, Gorski D, Evans H, Nguyen Q, Harrison D, Al-Lahham R, De Gregorio Carbonell N, Pinho M, Kaalund S, Folke J, Aznar S, Concha-Marambio L, Ishtikhar M, Mallampalli VK, Pritzkow S, Shahnawaz M, Baker ML, Serysheva I, Soto C.

Nat Commun · 2025-12-10

DOI: 10.1038/s41467-025-66146-4PMID: 41372188

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
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Nitrated products formed on α-synuclein are preferentially incorporated into oligomers but excluded from fibrils: A mechanism for accumulation of neurotoxic species.

Otzen DE, Gamon LF, Hägglund P, Nielsen J, Pedersen JN, Nybo T, Nowak JS, Amstrup SK, Pirhaghi M, Davies MJ.

Biochim Biophys Acta Proteins Proteom · 2025-12-10

DOI: 10.1016/j.bbapap.2025.141118PMID: 41386361

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.

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