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SCIENTIFIC LITERATURE · MED

Effects of dopamine on sensitivity to social bias in Parkinson's disease.

PLoS One · 2012-03-09

DOI: 10.1371/journal.pone.0032889PMID: 22427905

Open accessResearch Support, N.I.H., Intramural; Comparative Study; Research Support, Non-U.S. Gov't; research-article; Journal ArticleOriginal source ↗

Research overview

The text below is the source article’s original abstract under a verified reuse license. cc0

Patients with Parkinson's disease (PD) sometimes develop impulsive compulsive behaviours (ICBs) due to their dopaminergic medication. We compared 26 impulsive and 27 non-impulsive patients with PD, both on and off medication, on a task that examined emotion bias in decision making. No group differences were detected, but patients on medication were less biased by emotions than patients off medication and the strongest effects were seen in patients with ICBs. PD patients with ICBs on medication also showed more learning from negative feedback and less from positive feedback, whereas off medication they showed the opposite effect.

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