NeuralCipher Research overview
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ObjectiveThe short-term benefits of bilateral stimulation of the subthalamic nucleus (STN) in patients with advanced Parkinson's disease (PD) are well documented, but long-term benefits are still uncertain. The aim of this study is to evaluate the outcome of 8 years of bilateral STN stimulation to PD patients.MethodsIn this study, 31 consecutive PD patients were treated with bilateral STN stimulation. Their functional status was measured using the Activities of Daily Living section of the Unified Parkinson's Disease Rating Scale (UPDRS-ADL) at drug on (with medication) and drug off (without medication) states preoperatively and at 1, 5, and 8 years postoperatively. In addition, Levodopa equivalent doses and stimulation parameters were also assessed.ResultsAfter 8 years of STN stimulation, the UPDRS-ADL scores were improved by 4% at drug off status (P > 0.05) and 22% at drug on status (P ConclusionsThe marked improvement in UPDRS-ADL scores were still observed after 8 years of bilateral STN stimulation with medication.
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