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BackgroundPatients with essential tremor (ET) seem to be at increased risk of developing Parkinson's disease (PD). Surprisingly, little has been written about this clinical entity, ET-PD. Cognitive dysfunction is a well-known feature of PD, and can also be an issue in patients with ET. Whether the presence of the combined diagnosis, ET-PD, is associated with additive cognitive effects as compared with PD has not been studied.MethodsThirty ET-PD patients and 53 age-matched PD patients were enrolled in a clinical-epidemiological study. Two cognitive screens, the Telephone Interview for Cognitive Status (TICS, score = 0-41) and Folstein Mini-Mental State Examination (MMSE; range 0-30), were administered.ResultsThe MMSE score was lower in ET-PD than PD [26.5 ± 3.1 (median 28.0) vs. 28.4 ± 2.2 (median 29.0), p = 0.001]. The TICS score was lower in ET-PD than PD [31.7 ± 3.9 (32.0) vs. 35.0 ± 2.0 (35.0), p ConclusionThe combined diagnosis, ET-PD, seemed to be associated with additive cognitive effects as compared with PD alone.
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