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SCIENTIFIC LITERATURE · MED

Clustered Desynchronization from High-Frequency Deep Brain Stimulation.

PLoS Comput Biol · 2015-12-29

DOI: 10.1371/journal.pcbi.1004673PMID: 26713619

Open accessresearch-article; Research Support, U.S. Gov't, Non-P.H.S.; Journal ArticleOriginal source ↗

Research overview

The text below is the source article’s original abstract under a verified reuse license. cc by

While high-frequency deep brain stimulation is a well established treatment for Parkinson's disease, its underlying mechanisms remain elusive. Here, we show that two competing hypotheses, desynchronization and entrainment in a population of model neurons, may not be mutually exclusive. We find that in a noisy group of phase oscillators, high frequency perturbations can separate the population into multiple clusters, each with a nearly identical proportion of the overall population. This phenomenon can be understood by studying maps of the underlying deterministic system and is guaranteed to be observed for small noise strengths. When we apply this framework to populations of Type I and Type II neurons, we observe clustered desynchronization at many pulsing frequencies.

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