NeuralCipher Research overview
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BackgroundFalls in Parkinson's disease (PD) are associated with significant injury, disability, hospitalization, and reduced quality of life.AimsTo identify modifiable medical causes of falls in a cohort of PD patients.MethodsEighty seven PD patients were interviewed and examined using validated scales assessing motor and nonmotor aspects of PD, comorbidities and medication use. The frequency of falls in the last month was the primary outcome measure. Falls were hypothesized to be associated with increasing age, advanced motor severity, particularly axial features (e.g., freezing and postural instability), and dyskinesia. Nonmotor features hypothesized to be associated with falls included; cognitive impairment, psychosis, sleep disorders, cardiovascular dysfunction, and ophthalmological and medical comorbidities.ResultsFallers had longer disease duration, higher Levodopa-equivalent doses, greater 'On' time with dyskinesia (all P P P ConclusionsThe causes of falls in PD are multifactorial and extend beyond motor impairment and dyskinesia; addressing these in patients already treated with dopaminergic medications has the potential to improve this important complication of PD.
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