L-dopa treatment increases oscillatory power in the motor cortex of Parkinson's disease patients.

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Parkinson's disease (PD) is a movement disorder caused by dopaminergic neurodegeneration. Levodopa (L-dopa) is an effective medication for alleviating motor symptoms in PD that has been shown previously to reduce subcortical beta (13-30 Hz) oscillations. How L-dopa influences oscillations in the motor cortex is unclear. In this study, 21 PD patients were recorded with magnetoencephalography (MEG) in L-dopa ON and OFF states. Oscillatory components of resting-state power spectra were compared between the two states and the significant effect was localized using beamforming. Unified Parkinson's Disease Rating Scale (UPDRS) III akinesia and rigidity sub-scores for the most affected hemibody were correlated with source power values for the contralateral hemisphere. An L-dopa-induced power increase was found over the central sensors significant in the 18-30 Hz range (F(1,20)  > 14.8, PFWE corr (2, 19) = 4.9, pone-tailed = 0.02, R2 = 0.2). Power in the same range was also inversely correlated with combined akinesia and rigidity scores in the L-dopa OFF state (F(2, 19) = 9.2, ptwo-tailed = 0.007, R2 = 0.33) but not in the L-dopa ON state (F(2, 19) = 0.27, ptwo-tailed = 0.6, R2 = 0.01). These results suggest that the role of motor cortical beta oscillations in PD is distinct from that of subcortical beta.

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