NeuralCipher Research overview
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BackgroundCharacterization of patient factors associated with istradefylline efficacy may facilitate personally optimized treatment.ObjectivesWe aimed to examine which patient factors are associated with favorable istradefylline treatment outcomes in PD patients with motor complications.MethodsWe performed a pooled analysis of data from two identical phase 2b and 3 Japanese studies of istradefylline. Logistic regression models were used to assess the association of 12 patient characteristics with favorable outcomes.ResultsOff time reduction and increased good on time with istradefylline provided a significantly favorable response in patients aged ≥65 years. Off time reduction was more favorable in patients with ≥8-hour daily off time at baseline. Improvement in UPDRS Part III was favorable in patients with UPDRS Part III baseline score ≥ 20.ConclusionsSeveral patient factors influenced the effect of istradefylline on motor fluctuations, motor function, activities of daily living, and clinical impression. © 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
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