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BackgroundNon-motor fluctuations (NMF) in people with Parkinson's disease (PwP) are clinically important yet understudied.ObjectiveTo study NMF in PwP using both the Movement Disorder Society Non-Motor Rating Scale (MDS-NMS) NMF subscale and wearable sensors.MethodsWe evaluated differences in overall burden of NMF and of specific NMF across disease durations: 10 years (n = 31). In addition, wearable triaxial sensor output was used as an exploratory outcome for early morning "off" periods.ResultsSignificant between-group differences were observed for MDS-NMS NMF total scores (P 10 years this was 71.0% (P P ConclusionsNon-motor fluctuations prevalence in PwP increases with disease duration, but in a pattern different from motor fluctuations. Moreover, NMF can occur in PwP without dyskinesia, and in those with NMF the severity of NMF increases most during years 2-5 after diagnosis.
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