NeuralCipher Research overview
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BackgroundTask specific tremor (TST) is a poorly understood entity without any standard treatments, that may subsequently develop tremor during additional tasks, later develop postural/kinetic tremor (essential tremor criteria), and later develop Parkinson's disease. The pathophysiology is not understood as it has features of tremor, dystonia, and parkinsonism.ObjectivesTo assess response of TST to apomorphine and thus infer pathophysiology.MethodsWe administered sublingual apomorphine to 8 patients diagnosed with Parkinson's disease based on clinical criteria and dopamine imaging, who all initially presented with TST and later presented other parkinsonian signs and dopamine imaging deficits.ResultsApomorphine improved TST, which was refractory to oral levodopa and other tremor therapies, in 6/8 subjects.DiscussionThese results offer a treatment option for TST, which is usually refractory to other pharmacologic treatments, in patients with other parkinsonian features, and infers a dopaminergic pathophysiology of TST.
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