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SCIENTIFIC LITERATURE · MED

Spatial multimodal analysis of transcriptomes and metabolomes in tissues.

Nat Biotechnol · 2023-09-04

DOI: 10.1038/s41587-023-01937-yPMID: 37667091

Open accessresearch-article; Journal ArticleOriginal source ↗

Research overview

The text below is the source article’s original abstract under a verified reuse license. cc by

We present a spatial omics approach that combines histology, mass spectrometry imaging and spatial transcriptomics to facilitate precise measurements of mRNA transcripts and low-molecular-weight metabolites across tissue regions. The workflow is compatible with commercially available Visium glass slides. We demonstrate the potential of our method using mouse and human brain samples in the context of dopamine and Parkinson's disease.

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