NeuralCipher Research overview
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ObjectiveTo assess transcranial sonography (TCS) as stand-alone tool and in combination with microelectrode recordings (MER) as a method for the postoperative localization of deep brain stimulation (DBS) electrodes in the subthalamic nucleus (STN).MethodsIndividual dorsal and ventral boundaries of STN (n = 12) were determined on intraoperative MER. Postoperatively, a standardized TCS protocol was applied to measure medio-lateral, anterior-posterior and rostro-caudal electrode position using visualized reference structures (midline, substantia nigra). TCS and combined TCS-MER data were validated using fusion-imaging and clinical outcome data.ResultsTest-retest reliability of standard TCS measures of electrode position was excellent. Computed tomography and TCS measures of distance between distal electrode contact and midline agreed well (Pearson correlation; r = 0.86; p ConclusionsCombined TCS-MER data allow for exact localization of STN-DBS electrodes.SignificanceOur method provides a new option for monitoring of STN-DBS electrode location and guidance of DBS programming in Parkinson's disease.
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