NeuralCipher Research overview
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ObjectiveTo characterize sleep duration and investigate its association with quality of life among Parkinson's Disease (PD) patients.MethodsIn this multicenter cross-sectional study, 970 PD patients were divided into five groups based on self-reported sleep duration: 8 h. The quality of life was evaluated using the 39-Item Parkinson's Disease Questionnaire (PDQ-39). Multivariable linear regression analysis, subgroup analysis, and mediation analysis were conducted to examine the association between sleep duration and quality of life.ResultsIn multivariable linear regression model, patients with sleep duration (ConclusionsShort sleep duration (<5 h) is associated with worse quality of life among PD patients. This association was stronger among patients with advanced PD and sleep disorders, while non-motor symptoms and motor complications were identified as significant mediators in this association. These findings highlight the significance of adequate sleep duration and suitable interventions for sleep may help improve quality of life.
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