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SCIENTIFIC LITERATURE · MED

Pseudo-Orthostatic Tremor in Graves' Disease: A Possible Early Sign of Parkinsonism?

Tremor Other Hyperkinet Mov (N Y) · 2024-07-24

DOI: 10.5334/tohm.924PMID: 39070061

Open accessResearch Support, Non-U.S. Gov't; Journal Article; Case Reports; case-reportOriginal source ↗

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The text below is the source article’s original abstract under a verified reuse license. cc by

BackgroundPseudo-orthostatic tremor is a hyperkinetic movement disorder usually associated with other neurological comorbidities, mainly Parkinson's disease.Case reportA 65-year-old male presented with unsteadiness and leg tremor while standing. Electrophysiological evaluation confirmed the presence of pseudo-orthostatic tremor. Blood test showed an undiagnosed Graves' disease. A complete remission of tremor was achieved with methimazole. Dopamine transporter scintigraphy showed a mild reduction of the striatal binding, bilaterally.DiscussionGraves' disease can be associated with pseudo-orthostatic tremor. Thyroid function should be assessed in patients complaining of unsteadiness. The causative role of hyperthyroidism in determining dopaminergic degeneration and uncovering subclinical parkinsonism warrants further investigations.

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