NeuralCipher Research overview
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Levodopa (l-Dopa), a precursor drug for dopamine has been widely used to treat Parkinson's disease. However, excess accumulation of l-Dopa in the body may cause movement disorders and uncontrollable emotions. Therefore, it is vital to monitor l-Dopa levels in patients. In this study, a carbon dot (CD)-based fluorescence sensing system was developed for sensitive detection of l-Dopa. The CDs were prepared using a novel biomass, Pandanus amaryllifolius Roxb., as a carbon source via a simple hydrothermal method. Interestingly, it was found that ethylenediamine doping in the preparation system increased the quantum yield of CDs, as well as their fluorescence response sensitivity to l-Dopa. After optimizing the preparation and sensing conditions, the detection limit of l-Dopa decreased from 1.54 μM to 0.05 μM. A complete methodological validation was conducted and the probe was successfully applied to the determination of l-Dopa in fetal bovine serum with excellent precision (RSD ≤ 2.99%) and recoveries of 88.50-99.71%. Overall, this work provides an effective strategy for the regulation of properties of CDs derived from biomass and an innovative method for clinical l-Dopa monitoring.
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