NeuralCipher Research overview
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BackgroundIsolated REM sleep behavior disorder (iRBD) indicates an early α-synucleinopathy with approximately 90% of individuals pheno-converting to Parkinson's disease (PD), dementia with Lewy bodies (DLB), or multiple system atrophy (MSA). Recently, prodromal disease definitions (pPD, pDLB, pMSA) have been introduced.ObjectiveTo investigate the overlap of prodromal definitions in an established iRBD cohort.MethodsWe applied the current diagnostic criteria for pPD, pDLB, and pMSA to N = 55 individuals from the local iRBD cohort.ResultsAll except two individuals fulfilled at least one of the prodromal disease definitions; most individuals were classified as pPD (94.5%). 56% of the individuals fulfilled more than one definition: 32.7% pMSA&pPD, 10.9% pDLB&pPD, and 12.7% all three (pPD&pDLB&pMSA). The cognitive screening [(pPD = pMSA) > pDLB], motor symptoms [pPD ConclusionsThe observed overlap leads to challenges in patient counseling and risk disclosure. Better discrimination will facilitate research in early α-synucleinopathy phases.
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