SCIENTIFIC LITERATURE · MED

Dyskinesia-Hyperpyrexia Syndrome in Parkinson's Disease May Benefit from GPi Deep Brain Stimulation: A Case Report.

Huang SS, Ma LL, Sheng HS, Liu RP, Zhu SG, Xu SS, Sheng ML, Chen ZL, Zhang N, Zhang X, Wang JY.

Tremor Other Hyperkinet Mov (N Y) · 2025-05-07

Open accessResearch Support, Non-U.S. Gov't; Journal Article; Case Reports; case-reportOriginal source ↗

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BackgroundDyskinesia-hyperpyrexia syndrome (DHS) is a rare but life-threatening complication in Parkinson's disease (PD). Its prevention and treatment are clinical challenges.Case reportWe herein present a case of a female PD patient who experienced recurrent episodes of DHS and levodopa-induced dyskinesia. The complications were alleviated after bilateral globus pallidus internus (GPi) deep brain stimulation (DBS).DiscussionOur report provides evidence that GPi DBS may reduce the susceptibility to DHS. More evidences are warranted to validate this hypothesis.

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