Examining the Relationship Between Physical Function and Anxiety/Depression in Parkinson's.

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BackgroundParkinson's disease (PD) is a complex neurological disorder characterized by both motor and nonmotor symptoms, including tremor, muscle stiffness, anxiety, and depression.ObjectivesThe primary aim of this study was to examine the relationship between physical function and psychological symptoms, specifically anxiety and depression, in people with Parkinson's (PwP). The secondary aim was to explore whether any discrepancies between participant-reported and clinician-rated measures of physical function exist.MethodsThis study utilized the Parkinson's Progression Markers Initiative (PPMI) dataset, analyzing data from 1065 individuals with PD. Correlational analyses assessed relationships between clinician-rated and participant-reported motor outcomes alongside psychological symptoms. Multiple linear regression (MLR) was employed to identify predictors of anxiety and depression.ResultsIn PwP, significant correlations were found between depression/anxiety and participant-reported motor function (via MDS-UPDRS Part II: r = 0.313 for depression, r = 0.284 for anxiety, p ConclusionsThis study highlights a discrepancy between psychological symptoms and their relationship with clinician-rated versus participant-reported motor function in PwP. Our findings suggest that factors such as age, cognitive level, and perceived physical function significantly influence this relationship. Consequently, it is crucial to consider psychological factors and participant-reported motor function when conducting clinical assessments and treatment planning for individuals with PD.

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