NeuralCipher Research overview
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ObjectiveThis study aimed to determine if there are deficits in force variability, force increase, force decrease and force errors in rapid eye movement behavior disorder (RBD) using established force control paradigms.MethodsA cohort of 27 controls, 37 RBD and 37 early-stage Parkinson's disease (PD) were investigated. Individuals completed constant force and ballistic force control for the finger and ankle.ResultsThere was greater force variability in RBD compared with controls and PD during the constant force tasks (p ConclusionThese findings provide new evidence that force variability may be one of the earliest markers of motor dysfunction in RBD before a subsequent diagnosis of neurological disease.SignificanceThese findings provide new and important insights into the motor physiological changes in force control in RBD and PD, which may inform future biomarker studies.
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